Hematology Unit, Second Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Int J Mol Sci. 2022 Mar 29;23(7):3738. doi: 10.3390/ijms23073738.
Mitochondria are the most complex intracellular organelles, their function combining energy production for survival and apoptosis facilitation for death. Such a multivariate physiology is structurally and functionally reflected upon their membrane configuration and lipid composition. Mitochondrial double membrane lipids, with cardiolipin as the protagonist, show an impressive level of complexity that is mandatory for maintenance of mitochondrial health and protection from apoptosis. Given that lipidomics is an emerging field in cancer research and that mitochondria are the organelles with the most important role in malignant maintenance knowledge of the mitochondrial membrane, lipid physiology in health is mandatory. In this review, we will thus describe the delicate nature of the healthy mitochondrial double membrane and its role in apoptosis. Emphasis will be given on mitochondrial membrane lipids and the changes that they undergo during apoptosis induction and progression.
线粒体是最复杂的细胞内细胞器，其功能结合了生存所需的能量产生和促进死亡的细胞凋亡。这种多变量的生理学在其膜结构和脂质组成上得到了结构和功能上的体现。线粒体双层膜脂质以心磷脂为主角，表现出令人印象深刻的复杂性，这对于维持线粒体健康和防止细胞凋亡是必需的。鉴于脂质组学是癌症研究中的一个新兴领域，而线粒体是维持恶性肿瘤最重要的细胞器，因此了解健康线粒体膜的脂质生理学是必不可少的。在这篇综述中，我们将描述健康线粒体双层膜的微妙性质及其在细胞凋亡中的作用。重点将放在线粒体膜脂质上，并描述它们在细胞凋亡诱导和进展过程中所经历的变化。
