Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy, c/o Department of Biology and Biotechnology, Sapienza University of Rome, Via degli Apuli 4, 00185 Rome, Italy.
Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Int J Mol Sci. 2022 Mar 29;23(7):3784. doi: 10.3390/ijms23073784.
Telomeres are crucial structures that preserve genome stability. Their progressive erosion over numerous DNA duplications determines the senescence of cells and organisms. As telomere length homeostasis is critical for cancer development, nowadays, telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere dysfunction impinges on intracellular signaling pathways, in particular DNA damage signaling and repair, affecting cancer cell survival and proliferation. This review summarizes and discusses recent findings in anticancer drug development targeting different "telosome" components.
端粒是维持基因组稳定性的关键结构。在多次 DNA 复制过程中端粒的逐渐损耗决定了细胞和生物体的衰老。由于端粒长度的动态平衡对癌症的发展至关重要，因此目前端粒维持机制已成为癌症治疗的靶点。除了端粒延长外，端粒功能障碍还会影响细胞内信号通路，特别是 DNA 损伤信号和修复，从而影响癌细胞的存活和增殖。本文综述并讨论了针对不同“端粒体”成分的抗癌药物开发的最新发现。
