National Centre for Disease Prevention and Health Promotion, Istituto Superiore di Sanità (National Institute of Health), 00161 Rome, Italy.
National Centre for Drug Research and Evaluation, Istituto Superiore di Sanità (National Institute of Health), 00161 Rome, Italy.
Int J Environ Res Public Health. 2022 Apr 1;19(7):4186. doi: 10.3390/ijerph19074186.
Ensuring drug safety for pregnant women through prescription drug monitoring is essential. The aim of this study was to describe the prescription pattern of medicines among pregnant immigrant women from countries with high migratory pressure (HMPCs) compared to pregnant Italian women. The prevalence of drug prescriptions among the two study populations was analysed through record linkage procedures applied to the administrative databases of eight Italian regions, from 2016 to 2018. The overall prevalence of drug prescription was calculated considering all women who received at least one prescription during the study period. Immigrants had a lower prevalence of drug prescriptions before (51.0% vs. 58.6%) and after pregnancy (55.1% vs. 60. 3%). Conversely, during pregnancy, they obtained a slightly higher number of prescriptions (74.9% vs. 72.8%). The most prescribed class of drugs was the blood and haematopoietic organs category (category ATC B) (56.4% vs. 45.9%, immigrants compared to Italians), followed by antimicrobials (31.3% vs. 33.7%). Most prescriptions were appropriate, while folic acid administration 3 months before conception was low for both study groups (3.9% immigrants and 6.2% Italians). Progesterone seemingly was prescribed against early pregnancy loss, more frequently among Italians (16.5% vs. 8.1% immigrants). Few inappropriate medications were prescribed among antihypertensives, statins and anti-inflammatory drugs in both study groups.
通过处方药物监测确保孕妇用药安全至关重要。本研究旨在描述来自高移民压力国家（HMPCs）的移民孕妇与意大利孕妇的药物处方模式。通过将记录链接程序应用于 2016 年至 2018 年意大利八个地区的行政数据库，分析了两个研究人群的药物处方流行率。考虑到所有在研究期间至少收到一张处方的女性，计算了药物处方的总体流行率。移民在怀孕前（51.0%比 58.6%）和怀孕后（55.1%比 60.3%）的药物处方流行率较低。相反，在怀孕期间，他们获得的处方数量略高（74.9%比 72.8%）。处方最多的药物类别是血液和造血器官类（ATC B 类）（56.4%比 45.9%，移民比意大利人），其次是抗生素（31.3%比 33.7%）。大多数处方是合适的，然而，两组叶酸的给药时间都不理想（移民 3.9%，意大利人 6.2%）。孕激素似乎用于治疗早期妊娠丢失，意大利人（16.5%比移民 8.1%）的处方更频繁。两组研究对象的降压药、他汀类药物和抗炎药中，开的不合适药物很少。
