铅的遗传毒性及其对 DNA 修复基因表达的影响。
Genotoxic Effects of Lead and Their Impact on the Expression of DNA Repair Genes.
机构信息
Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Rangsit 12121, Thailand.
Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Rangsit 12121, Thailand.
出版信息
Int J Environ Res Public Health. 2022 Apr 3;19(7):4307. doi: 10.3390/ijerph19074307.
Abstract
Exposure to lead (Pb) continues to be a significant worldwide problem. Pb is a highly poisonous heavy metal affecting several organ systems in the body. Although Pb has been shown to be genotoxic to experimental animals and humans, the underlying mechanisms are still not understood. An indirect mechanism related to the inhibition of DNA repair systems by Pb has been suggested. Heavy metals can interfere with the activities of several proteins and gene expressions. Recent studies gathered in this review article demonstrated an altered expression of DNA repair genes due to Pb toxicity. However, their findings are conflicting. Furthermore, the interaction of Pb and epigenetic mechanisms regulating gene expression may have a crucial role in the inhibition of DNA repair systems. Therefore, additional studies are needed to evaluate these findings and to obtain a complete picture of the genotoxic properties of Pb and the underlying mechanisms that may have a crucial role in carcinogenesis.
摘要
暴露于铅（Pb）仍然是一个全球性的重大问题。Pb 是一种剧毒重金属，会影响体内的几个器官系统。尽管已经证明 Pb 对实验动物和人类具有遗传毒性，但其中的机制仍未被完全理解。有研究提出，Pb 通过抑制 DNA 修复系统来产生间接作用。重金属可以干扰多种蛋白质和基因表达的活性。这篇综述文章中汇集的最新研究表明，Pb 毒性会导致 DNA 修复基因的表达发生改变。然而，他们的研究结果存在冲突。此外，Pb 与调节基因表达的表观遗传机制的相互作用可能在抑制 DNA 修复系统中发挥关键作用。因此，需要进一步的研究来评估这些发现，并全面了解 Pb 的遗传毒性特性及其在致癌作用中可能发挥关键作用的潜在机制。
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