ENT and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Ferrara, Ferrara, Italy -
ENT and Audiology Unit, Department of Neurosciences and Rehabilitation, University of Ferrara, Ferrara, Italy.
Minerva Anestesiol. 2022 Apr;88(4):293-299. doi: 10.23736/S0375-9393.21.16037-7.
The aim of this study was to revise the etiologic features about Tapia's Syndrome (TS), a condition to particularly consider in the era of the COVID-19 pandemic.
A systematic review was performed according to the PRISMA criteria. The Medline and Embase databases were searched from January 1, 1990, to December 31, 2020. Initially the search yielded 399 manuscripts, which were reduced to 50, upon the application of inclusion criteria.
A total of 65 patients were included in the present review. Mean age was 44±17.5 (DS) years (15-95); M:F ratio was 2.3:1. TS involved mainly the left side (3:2) and was rarely bilateral. Only 2 TS reported cases were due to central causes. Peripheral causes were mainly due to postintubation edema (77%), extrinsic compression (15%), vascular disease (3%), other/not defined (5%).
TS is a rare syndrome that has been related to a combined cranial nerve palsy; while TS due to central causes is very rare, it is mainly related to peripheral causes. A particular attention to TS should be given during the SARS-CoV-2 pandemic, either since the correlation between Tapia's syndrome, airway management and anesthetic procedures, since the possible implication of the viral infection itself.
本研究旨在修订 Tapia 综合征（TS）的病因特征，这是 COVID-19 大流行时代需要特别考虑的一种情况。
根据 PRISMA 标准进行了系统评价。从 1990 年 1 月 1 日至 2020 年 12 月 31 日，检索了 Medline 和 Embase 数据库。最初的搜索结果产生了 399 篇手稿，在应用纳入标准后，将其减少到 50 篇。
本综述共纳入 65 例患者。平均年龄为 44±17.5（DS）岁（15-95）；男女比例为 2.3:1。TS 主要累及左侧（3:2），很少双侧受累。仅报告了 2 例 TS 为中枢原因所致。外周原因主要是由于插管后水肿（77%）、外在压迫（15%）、血管疾病（3%）、其他/未定义（5%）。
TS 是一种罕见的综合征，与联合颅神经麻痹有关；虽然中枢原因引起的 TS 非常罕见，但主要与外周原因有关。在 SARS-CoV-2 大流行期间，应特别注意 TS，因为 Tapia 综合征、气道管理和麻醉程序之间存在关联，并且病毒感染本身也可能有影响。
