Materials Genome Institute, and Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China.
Institute of Molecular Medicine (IMM), Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University, Shanghai 200240, China.
Soft Matter. 2022 Apr 20;18(16):3125-3129. doi: 10.1039/d2sm00148a.
A novel helix hydrogel with a G-quartet structure was synthesized from guanosine (Gua) and its derivative 5'-guanosine monophosphate (5'-GMP) under a molecular crowding environment. The chirality of the hydrogel is adjusted by controlling the gelling speed. The chiral hydrogel can induce an achiral dye Thioflavin T (ThT) to realize circularly polarized fluorescence (CPL). The CPL dissymmetry factor || of the dye-hydrogels can reach 3 × 10 and can be switched easily.
一种新型的具有 G-四联体结构的螺旋水凝胶，是在分子拥挤环境下由鸟苷（Gua）及其衍生物 5'-单磷酸鸟苷（5'-GMP）合成的。通过控制凝胶速度来调节水凝胶的手性。手性水凝胶可以诱导非手性染料硫黄素 T（ThT）实现圆偏振荧光（CPL）。染料-水凝胶的圆二色性因子||可达 3×10，且易于切换。
