Kang Jae H, Vyas Chirag M, Okereke Olivia I, Ogata Soshiro, Albert Michelle, Lee I-Min, D'Agostino Denise, Buring Julie E, Cook Nancy R, Grodstein Francine, Manson JoAnn E
Channing Division of Network Medicine Brigham and Women's Hospital/Harvard Medical School Boston Massachusetts USA.
Department of Psychiatry Massachusetts General Hospital/Harvard Medical School Boston Massachusetts USA.
Alzheimers Dement (N Y). 2022 Apr 5;8(1):e12288. doi: 10.1002/trc2.12288. eCollection 2022.
: Few large, randomized trials have evaluated marine n-3 supplements and cognition in healthy older adults.
: Healthy community-dwelling participants aged 60+ years (mean [standard deviation] = 70.9 [5.8] years) in VITAL (randomized trial of n-3 fats [1 g/day, including 840 mg of eicosapentaenoic acid + docosahexaenoic acid] and vitamin D) were included: 3424 whose cognition was assessed by phone (VITAL-Cog; eight neuropsychological tests; 2.8 years) and 794 evaluated in person (CTSC-Cog; nine tests; 2.0 years). The primary outcome was a global score (average of test z-scores) of change over two assessments. We used multivariable-adjusted linear mixed models; substudy-specific results were meta-analyzed.
: We observed no significant effect of n-3 supplementation: the mean difference in annual rate of cognitive change for the n-3 versus placebo group was -0.01 standard units (95% confidence interval [CI]: -0.02, 0.003) in VITAL-Cog and -0.002 (95% CI: -0.04, 0.03) in CTSC-Cog; the pooled difference was -0.01 (95% CI: -0.02, 0.003; = .15).
: Marine n-3 supplementation (1 g/day) did not confer cognitive benefits over 2 to 3 years in community-dwelling older adults.
很少有大型随机试验评估海洋n-3补充剂对健康老年人认知功能的影响。
纳入了VITAL（n-3脂肪酸[1克/天，包括840毫克二十碳五烯酸+二十二碳六烯酸]和维生素D的随机试验）中60岁及以上的健康社区居民参与者（平均[标准差]=70.9[5.8]岁）：3424人通过电话评估认知功能（VITAL-Cog；八项神经心理学测试；2.8年），794人进行了面对面评估（CTSC-Cog；九项测试；2.0年）。主要结局是两次评估中变化的综合评分（测试z分数的平均值）。我们使用多变量调整线性混合模型；对亚研究的特定结果进行了荟萃分析。
我们观察到补充n-3没有显著效果：在VITAL-Cog中，n-3组与安慰剂组的认知变化年率平均差异为-0.01标准单位（95%置信区间[CI]：-0.02，0.003），在CTSC-Cog中为-0.002（95%CI：-0.04，0.03）；合并差异为-0.01（95%CI：-0.02，0.003；P = 0.15）。
在社区居住的老年人中，补充海洋n-3（1克/天）在2至3年内未带来认知益处。
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