Gao Yifang, Liu Xueting, Yang Wenqing, Li Xixi, Li Mengru, Li Fengjuan
Key Laboratory of Food Nutrition and Safety (Tianjin University of Science and Technology), Ministry of Education Tianjin 300457 PR China
RSC Adv. 2022 Feb 2;12(7):4191-4198. doi: 10.1039/d1ra08978a. eCollection 2022 Jan 28.
In order to explore novel blood pressure-regulating substances and fulfill the high-value utilization of various edible flowers, the inhibitory activities of aqueous solutions of 22 edible flower petals extracts on renin and angiotensin converting enzyme (ACE) were investigated. The results showed that almost all the aqueous sample extracts demonstrated an inhibition of renin and/or ACE. The Rosa rugosa Thunb. (IC = 25.13 and 60.00 μg mL) and Paeonia suffruticosa Andr. (IC = 50.54 and 292.47 μg mL) extracts showed prominent dual inhibitory activity against renin and ACE. The antioxidant activities and content of total phenols and flavonoids of the aqueous sample extracts were tested, because the oxidative damage of blood vessels is closely related to the occurrence and development of hypertension. The correlation between the contents of total phenolic substances and flavonoids, and the functional activities was analyzed. Renin and ACE inhibitory activities, DPPH and ABTS free radical scavenging capacity, and iron reduction ability of different sample extracts were significantly positively correlated with the total phenolic content ( <0.01), whereby the correlation coefficients were 0.87, 0.83, 0.93, 0.95, and 0.93 respectively. It was indicated that the aqueous phenolic compounds in Rosa rugosa Thunb and Paeonia suffruticosa Andr extracts tended to show stronger renin and ACE inhibitory activities, and exhibited a potential prospect for auxiliary blood pressure control.
为了探索新型血压调节物质并实现各种可食用花卉的高值化利用，研究了22种可食用花瓣提取物水溶液对肾素和血管紧张素转换酶（ACE）的抑制活性。结果表明，几乎所有的样品水提取物均表现出对肾素和/或ACE的抑制作用。玫瑰（IC = 25.13和60.00 μg/mL）和牡丹（IC = 50.54和292.47 μg/mL）提取物对肾素和ACE表现出显著的双重抑制活性。测试了样品水提取物的抗氧化活性以及总酚和黄酮类化合物的含量，因为血管的氧化损伤与高血压的发生和发展密切相关。分析了总酚类物质和黄酮类化合物含量与功能活性之间的相关性。不同样品提取物的肾素和ACE抑制活性、DPPH和ABTS自由基清除能力以及铁还原能力与总酚含量呈显著正相关（<0.01），相关系数分别为0.87、0.83、0.93、0.95和0.93。结果表明，玫瑰和牡丹提取物中的水溶性酚类化合物倾向于表现出更强的肾素和ACE抑制活性，并在辅助控制血压方面展现出潜在前景。
