State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China; College of Food and Biological Engineering, Zhengzhou University of Light Industry, Henan 450002, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Bioorg Chem. 2019 Feb;82:139-144. doi: 10.1016/j.bioorg.2018.10.007. Epub 2018 Oct 6.
Flower of Chrysanthemum morifolium is widely used in China and Japan as a folk medicine in treatment of many diseases. However, its active compounds remain largely unknown. In the present work, we have isolated, purified and characterized six new compounds (1-6), including two new arylnaphthalene lignans and four new phenolic glycosides, together with eight known compounds (7-14), from the flower of C. morifolium. Their structures and absolute configurations were elucidated in detail using 1D and 2D NMR, UV, IR, ORD, HRESIMS and ECD spectrometric data. In addition, compounds 1-3 possessed the significant neuroprotective activity against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.
菊花在我国和日本被广泛用作民间药物，用于治疗许多疾病。然而，其活性化合物在很大程度上仍是未知的。在本工作中，我们从菊花中分离、纯化并鉴定了六个新化合物（1-6），包括两个新的芳基萘木脂素和四个新的酚糖苷，以及八个已知化合物（7-14）。它们的结构和绝对构型通过 1D 和 2D NMR、UV、IR、ORD、HRESIMS 和 ECD 光谱数据得到了详细阐明。此外，化合物 1-3 对人神经母细胞瘤 SH-SY5Y 细胞中海氧自由基诱导的神经毒性具有显著的神经保护活性。
