Saeed Sajeel, Rauf Khalid Abdul, Farhan Muhammad, Basit Jawad, Tousif Kashif, Haider Tehseen, Us Sabah Noor, Gondal Mudassar Fiaz, Ur Rehman Mohammad Ebad
Department of Surgery, Holy Family Hospital, Rawalpindi, PAK.
Department of Internal Medicine, Holy Family Hospital, Rawalpindi, PAK.
Cureus. 2022 Mar 14;14(3):e23136. doi: 10.7759/cureus.23136. eCollection 2022 Mar.
Background Anorectal malformations are congenital defects wherein there is defective development of the anus and rectum. For babies born with congenital anorectal malformations, prompt treatment is crucial which requires detection of the anomalies at the earliest. This study aimed to determine the epidemiology ofanorectal malformations in the Pediatric Unit of a tertiary care hospital in Pakistan over a period of 19 months. Methodology An analytical cross-sectional study was conducted retrospectively from January 2020 to September 2021 using a non-randomized consecutive sampling technique. Patients aged less than eight years were included, whereas burnt, torn, and incomplete records from the Hospital Management Information System (HMIS) were excluded. SPSS version 26 (IBM Corp., Armonk, NY, USA) was used for data entry and analysis. Binomial and multinomial logistic regression were applied for analyzing the association between explanatory and dependent variables. Results Of the 1,108 patients, 72 (6.5%) patients had anorectal malformations. Gastrointestinal diseases made up about 64.3% of all diseases. Among gastrointestinal causes, the prevalence of anorectal malformation was up to 10.1%. The mortality of anorectal malformation patients was low (2.85%) compared to mortalities due to other gastrointestinal abnormalities (8.25%). Anorectal malformation had significantly lower odds of mortality (adjusted odds ratio = 0.19, p < 0.05) compared to other gastrointestinal abnormalities. Conclusions This study has provided data about the prevalence of anorectal malformation and its mortality which were calculated as 6.5% and 2.58%, respectively. Female gender, neonates, and delayed presentation were seen to have higher mortality, highlighting the need to screen all neonates pre- and post-natally to avoid any misdiagnosis.
肛门直肠畸形是先天性缺陷,即肛门和直肠发育存在缺陷。对于患有先天性肛门直肠畸形的婴儿,及时治疗至关重要,这需要尽早发现异常情况。本研究旨在确定巴基斯坦一家三级医院儿科病房19个月期间肛门直肠畸形的流行病学情况。
采用非随机连续抽样技术,对2020年1月至2021年9月进行回顾性分析横断面研究。纳入年龄小于8岁的患者,排除医院管理信息系统(HMIS)中烧伤、撕裂和不完整的记录。使用SPSS 26版(美国纽约州阿蒙克市IBM公司)进行数据录入和分析。应用二项式和多项逻辑回归分析解释变量和因变量之间的关联。
在1108例患者中,72例(6.5%)患有肛门直肠畸形。胃肠道疾病约占所有疾病的64.3%。在胃肠道病因中,肛门直肠畸形的患病率高达10.1%。与其他胃肠道异常导致的死亡率(8.25%)相比,肛门直肠畸形患者的死亡率较低(2.85%)。与其他胃肠道异常相比,肛门直肠畸形的死亡几率显著较低(调整后的优势比=0.19,p<0.05)。
本研究提供了有关肛门直肠畸形患病率及其死亡率的数据,分别计算为6.5%和2.58%。女性、新生儿和就诊延迟者的死亡率较高,这突出表明需要在产前和产后对所有新生儿进行筛查,以避免任何误诊。