Department of Macromolecular Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka, 560-0043, Japan.
Department of Materials Engineering Science, Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan.
Macromol Biosci. 2022 Jun;22(6):e2200055. doi: 10.1002/mabi.202200055. Epub 2022 Apr 27.
Mucin-containing bio-synthetic hybrid hydrogel is successfully formed under physiological conditions upon mixing aqueous solutions of native mucin and synthetic polymers carrying boronic acids. The mechanical properties and stability of the hydrogel in physiological solutions, e.g., cell culture media, are tunable depending on the boronic acid content of polymers. The hydrogel dissolved in the physiological solutions releases native mucin and boronic acid-containing polymer, which can control the adhesion of mammalian cells to the surface.
在生理条件下，当含有硼酸的天然黏蛋白和合成聚合物的水溶液混合时，成功形成了含有黏蛋白的生物合成杂化水凝胶。水凝胶在生理溶液（例如细胞培养基）中的机械性能和稳定性可以根据聚合物中硼酸的含量进行调节。溶解在生理溶液中的水凝胶释放出天然黏蛋白和含有硼酸的聚合物，从而可以控制哺乳动物细胞在表面的黏附。
