J Am Vet Med Assoc. 2022 Apr 15;260(9):963-970. doi: 10.2460/javma.22.02.0088.
Aging is the single most important cause of disease, disability, and death in adult dogs. Contrary to the common view of aging as a mysterious and inevitable natural event, it is more usefully understood as a set of complex but comprehensible biological processes that are highly conserved across species. Although the phenotypic expression of these processes is variable, there are consistent patterns both within and between species. The purpose of this feature is to describe the patterns currently recognized in the physical and behavioral manifestations of aging in the dog and how these impact the health and welfare of companion dogs and their human caregivers. Important gaps in our knowledge of the canine aging phenotype will be identified, and current research efforts to better characterize aging in the dog will be discussed. This will help set the context for future efforts to develop clinical assessments and treatments to mitigate the negative impact of aging on dogs and humans.
衰老是导致成年犬患病、残疾和死亡的最主要原因。与将衰老视为一种神秘而不可避免的自然事件的普遍观点相反，将其理解为一系列复杂但可理解的生物学过程更为有用，这些过程在物种间高度保守。尽管这些过程的表型表达是可变的，但在物种内和物种间都存在一致的模式。本专题的目的是描述在犬衰老过程中的身体和行为表现方面目前公认的模式，以及这些模式如何影响伴侣犬及其人类照顾者的健康和福利。我们将确定在犬衰老表型方面知识的重要空白，并讨论当前为更好地描述犬衰老而进行的研究工作。这将有助于为未来开发临床评估和治疗方法以减轻衰老对犬和人类的负面影响奠定基础。
