Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
J Infect Dis. 2022 Nov 1;226(9):1551-1555. doi: 10.1093/infdis/jiac149.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant extensively escape neutralizing antibodies by vaccines or infection. We assessed serum neutralizing activity in sera from Delta infection after vaccination and Delta infection only against SARS-CoV-2 Wuhan-Hu-1 (WA1), Beta, Delta, and Omicron. Sera from Delta infection only could neutralize WA1 and Delta but almost completely lost capacity to neutralize Beta and Omicron. However, Delta infection after vaccination resulted in a significant increase of serum neutralizing activity against WA1, Beta, and Omicron. This study demonstrates that breakthrough infection of Delta substantially induced high potency humoral immune response against the Omicron variant and other emerged variants.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）奥密克戎（B.1.1.529）变体通过疫苗或感染广泛逃避中和抗体。我们评估了血清中和活性，血清来自 Delta 感染后的疫苗接种和 Delta 感染仅针对 SARS-CoV-2 武汉-Hu-1（WA1）、贝塔、德尔塔和奥密克戎。仅 Delta 感染的血清可中和 WA1 和德尔塔，但几乎完全丧失中和贝塔和奥密克戎的能力。然而，Delta 感染后的疫苗接种导致针对 WA1、贝塔和奥密克戎的血清中和活性显著增加。这项研究表明，Delta 的突破性感染大大诱导了针对奥密克戎变体和其他出现变体的高效力体液免疫反应。
