School of Dental Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
School of Dental Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
Eur J Pharmacol. 2022 Jun 5;924:174958. doi: 10.1016/j.ejphar.2022.174958. Epub 2022 Apr 14.
Dental pain is a common complaint in patients undergoing endodontic treatment. Despite continuous efforts to develop new pain management strategies and improved treatment approaches, dental pain management remains a continuous challenge to clinicians. Understanding pain signalling mechanisms in the dental pulp along with the molecular targets involved in the dental pain pathway will provide a better view of how dental pain can be managed. The role of γ-Aminobutyric acid (GABA) in pain transduction has been well explored in various literature over the years. GABA and its receptors have been found in parts of the spinal cord and brain that are related to pain perception, thus providing compelling evidence of its role in mediating pain signalling. Based on this evidence, several studies have investigated the expression of GABA and its receptors in the dental pulp as well as its role in dental pain transmission. This review discusses GABA and its receptors in pain signalling, with emphasis on the research progress related to GABAergic signalling in the dental pain pathway.
牙科疼痛是接受牙髓治疗的患者常见的主诉。尽管不断努力开发新的疼痛管理策略和改进治疗方法，但牙科疼痛管理仍然是临床医生面临的持续挑战。了解牙髓中的疼痛信号机制以及参与牙科疼痛途径的分子靶点，将更好地了解如何管理牙科疼痛。γ-氨基丁酸（GABA）在各种文献中的疼痛转导作用多年来得到了充分的研究。在与疼痛感知相关的脊髓和大脑的某些部位发现了 GABA 及其受体，从而为其在介导疼痛信号中的作用提供了有力的证据。基于这一证据，几项研究调查了 GABA 及其受体在牙髓中的表达及其在牙齿疼痛传递中的作用。本文综述了 GABA 及其受体在疼痛信号转导中的作用，重点介绍了与牙科疼痛途径中 GABA 能信号转导相关的研究进展。
