Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University, Chongqing 400715, PR China.
The First Affiliated Hospital of Xi'an Medical University, Xi'an, PR China.
Neurosci Biobehav Rev. 2022 Jun;137:104663. doi: 10.1016/j.neubiorev.2022.104663. Epub 2022 Apr 13.
Accumulating evidence suggests that individuals with a history of childhood adversity are at greater risk for developing depression. Potential psychological mechanisms have not been well-established. Our study aims to identify psychological variables consistently mediating/moderating the link between childhood adversity to depression. We systematically searched articles from 1990 to October 2021 on online databases including PubMed, Web of Science and PsycINFO. Studies that examined a mediating/moderating role of psychological variables between childhood adversities and depression were included. Totally, 33 records were included. The review identified maladaptive schema, negative automatic thoughts, and avoidance as mediators of the relationship between childhood adversity and depression. Additionally, resilience was identified as both a mediator and moderator of the association between childhood adversity and depression. In general, cognitive dysfunction, avoidance behaviors and impaired resilience may be a by-product of childhood adversity and may contribute to increased risk for depression. Interventions that target at challenging negative cognition and improving resilience may be effective to prevent or treat depression in individuals with a history of childhood adversity.
越来越多的证据表明，有童年逆境经历的个体更容易患上抑郁症。潜在的心理机制尚未得到充分证实。我们的研究旨在确定心理变量，这些变量可以在童年逆境与抑郁之间的关系中起到中介/调节作用。我们系统地检索了从 1990 年到 2021 年 10 月在在线数据库 PubMed、Web of Science 和 PsycINFO 上发表的文章。研究包括了检验心理变量在童年逆境与抑郁之间的中介/调节作用的文章。总共纳入了 33 篇记录。综述确定了不适应的图式、消极的自动思维和回避是童年逆境与抑郁之间关系的中介因素。此外，韧性被确定为童年逆境与抑郁之间关联的中介和调节因素。总的来说，认知功能障碍、回避行为和适应能力受损可能是童年逆境的一个副产品，并可能导致抑郁风险增加。针对挑战消极认知和提高适应能力的干预措施可能对预防或治疗有童年逆境经历的个体的抑郁症有效。
