Overall J E, Biggs J, Jacobs M, Holden K
J Clin Psychiatry. 1987 Jan;48(1):15-9.
A 6-week double-blind comparison of the therapeutic efficacy of alprazolam and imipramine in 90 depressed psychiatric outpatients revealed a significantly superior response to alprazolam in the first 2 weeks of treatment as measured by total scores on the Hamilton Rating Scale for Depression and the Brief Psychiatric Rating Scale. Further analyses revealed that all significant differences could be accounted for by the superior effect of alprazolam on sleep disturbance. By the end of Weeks 4 and 6, no significant differences in therapeutic response between the two treatment groups were noted, with patients in both groups evidencing improvement on all measures. A differentially high dropout rate among patients in the imipramine treatment group posed a problem for interpretation of results in the latter weeks of treatment.
对90名抑郁的精神科门诊患者进行的一项为期6周的阿普唑仑和丙咪嗪治疗效果双盲比较显示，在治疗的前2周，根据汉密尔顿抑郁评定量表和简明精神病评定量表的总分衡量，阿普唑仑的反应明显更优。进一步分析表明，所有显著差异都可归因于阿普唑仑对睡眠障碍的更佳疗效。到第4周和第6周结束时，两个治疗组在治疗反应上没有显著差异，两组患者在所有指标上均有改善。丙咪嗪治疗组患者中差异较大的高脱落率给治疗后期结果的解释带来了问题。
