Ashour Dina, AlSubaihin Abdulmajeed, Lim Yvonne Yijuan, Legault Laurent
Department of Biomedical Sciences, University of Montreal, Montreal, Quebec, Canada; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Obes Res Clin Pract. 2022 Mar-Apr;16(2):138-143. doi: 10.1016/j.orcp.2022.03.003. Epub 2022 Apr 13.
Overweight and obesity have been observed in children with type 1 diabetes (T1D). This further increases their future risk of Cardiovascular Disease (CVD) as well as the development of other risk factors, such as dyslipidemia.
To compare lipid profiles in children and adolescents with Type 1 diabetes and lean mass (T1L), Type 1 diabetes and overweight or obese (T1OW/OB), and type 2 diabetes (T2D).
This was a cross-sectional study of 669 patients with T1D or T2D aged 2-19 years using retrospective data collected from 2003 to 2014. Included patients were categorized into lean (BMI < 85th ile and overweight or Obese (BMI ≥ 85th ile). Patients were subcategorized into three age groups: < 10 years, 10-14 years, and 15-19 years.
7.6% of patients had T2D. Of the patients with T1D, 58.9% were lean, 26.4% were overweight, and 14.7% were obese. Total Cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C) and Non-HDL-C levels were similar across groups. In the 15-19 years group, Triglycerides (TG) levels were significantly higher in T1OW/OB and similar to T2D. High-density lipoprotein Cholesterol (HDL-C) was significantly lower in T2D. Weight status significantly correlated with TG and HDL-C levels in T1D and T2D groups.
T1OW/OB constitutes a significant proportion of the T1D population. Patients with obesity and T1D, especially if in their late adolescence, have an adverse lipid profile pattern that is comparable to adolescents with T2D. Based on these findings, risk for future CVD in T1OW/OB and T2D may be equivalent.
1型糖尿病（T1D）患儿中存在超重和肥胖现象。这进一步增加了他们未来患心血管疾病（CVD）的风险以及其他危险因素的发生，如血脂异常。
比较1型糖尿病伴瘦体重（T1L）、1型糖尿病伴超重或肥胖（T1OW/OB）的儿童和青少年以及2型糖尿病（T2D）患者的血脂谱。
这是一项对669例年龄在2至19岁的T1D或T2D患者的横断面研究，使用了2003年至2014年收集的回顾性数据。纳入的患者分为瘦（BMI<第85百分位数）、超重或肥胖（BMI≥第85百分位数）。患者又被细分为三个年龄组：<10岁、10至14岁和15至19岁。
7.6%的患者患有T2D。在T1D患者中，58.9%为瘦，26.4%为超重，14.7%为肥胖。各组间总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和非高密度脂蛋白胆固醇（Non-HDL-C）水平相似。在15至19岁年龄组中，T1OW/OB组的甘油三酯（TG）水平显著高于其他组，且与T2D组相似。T2D组的高密度脂蛋白胆固醇（HDL-C）显著降低。在T1D和T2D组中，体重状况与TG和HDL-C水平显著相关。
T1OW/OB在T1D人群中占相当大的比例。肥胖的T1D患者，尤其是在青春期后期，其血脂谱模式不良，与T2D青少年相当。基于这些发现，T1OW/OB和T2D未来发生心血管疾病（CVD）的风险可能相当。
