Palomo Atance E, Giralt Muiña P, Ballester Herrera M J, Ruiz Cano R, León Martín A, Giralt Muiña J
Unidad de Endocrinología Pediátrica, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
An Pediatr (Barc). 2013 Jun;78(6):382-8. doi: 10.1016/j.anpedi.2012.11.011. Epub 2012 Dec 28.
To establish the prevalence of overweight-obesity and metabolic syndrome in a group of paediatric patients with type 1 diabetes (DM1), and to determine the effects on the lipoprotein profile and metabolic control.
A group of 115 patients (5-16 years) with DM1, and on intensive insulin therapy was studied. Weight, height, body mass index (BMI), waist circumference (WC), blood pressure (BP), glycosylated haemoglobin (HbA1c), total cholesterol (TC), HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c) and triglycerides (TG) were measured. The results were stratified by sex and age (< 11 years and ≥ 11 years).
The prevalence of overweight and obesity (according to Hernández's reference values) was 28.69% and 18.26%, respectively, with female predominance in both cases. The prevalence of metabolic syndrome (according to the International Diabetes Federation criteria) was 3.22%. 3.47% The WC adjusted for age and sex was > 90th percentile in 3.47% of cases, and 2.6% had a systolic BP ≥ 130 mmHg and/or a diastolic BP ≥ 85 mmHg. An HDL-c < 40 mg/dl was seen in 4.34%, and 2.6% had TG ≥ 150 mg/dl. Obese patients had lower HDL-c levels and higher LDL-c levels than non-obese subjects. There were no significant differences in HbA1c between patients with overweight-obesity and the rest.
Overweight and obesity are common in paediatric patients with DM1. Nevertheless, the prevalence of metabolic syndrome and cardiovascular risk factors is lower than in adult patients. The group of diabetic children with obesity had a lipoprotein profile of cardiovascular risk.
确定一组1型糖尿病（DM1）儿科患者中超重-肥胖及代谢综合征的患病率，并确定其对脂蛋白谱和代谢控制的影响。
对一组115例年龄在5至16岁、接受强化胰岛素治疗的DM1患者进行研究。测量体重、身高、体重指数（BMI）、腰围（WC）、血压（BP）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）和甘油三酯（TG）。结果按性别和年龄（<11岁和≥11岁）分层。
超重和肥胖的患病率（根据埃尔南德斯的参考值）分别为28.69%和18.26%，两种情况均以女性为主。代谢综合征的患病率（根据国际糖尿病联盟标准）为3.22%。3.47%的病例经年龄和性别调整后的WC>第90百分位数，2.6%的患者收缩压≥130 mmHg和/或舒张压≥85 mmHg。4.34%的患者HDL-c<40 mg/dl，2.6%的患者TG≥150 mg/dl。肥胖患者的HDL-c水平低于非肥胖患者，LDL-c水平高于非肥胖患者。超重-肥胖患者与其他患者的HbA1c无显著差异。
超重和肥胖在DM1儿科患者中很常见。然而，代谢综合征和心血管危险因素的患病率低于成年患者。肥胖的糖尿病儿童组具有心血管风险的脂蛋白谱。
