Zhang Xia, Gao Ming, Rao Zhili, Lei Ziqin, Zeng Jiuseng, Huang Zhangjun, Shen Caihong, Zeng Nan
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, PR China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, PR China.
Luzhou Pinchuang Technology Co. Ltd., Luzhou, Sichuan, 646000, PR China.
J Ethnopharmacol. 2022 Jul 15;293:115300. doi: 10.1016/j.jep.2022.115300. Epub 2022 Apr 14.
Baishouwu has been used in China for thousands of years since it was first discovered in the late Tang Dynasty and flourished in the Song and Ming Dynasties. The Chinese herbal medicines named Baishouwu include Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii Hemsl. It is described in the Sign of Materia Medica as "sweet, bitter, reinforce liver and kidney, and non-toxic". It is widely used for nourishing the blood to expel wind, reinforcing liver and kidney, strengthening bones and muscles.
In this review, the current research status of the C steroidal glycosides and their derivatives of Baishouwu for malignant tumours and their anti-tumour mechanisms are discussed. This may lay the ground for potential application of Baishouwu and its active ingredients in the treatment of tumours.
Scientific databases, including PubMed, Elsevier, Science Direct, Google Scholar, CNKI, WANFANG DATA and VIP were searched to gather data about Baishouwu and its C steroidal glycosides and their derivatives.
Prior literature indicates that Baishouwu has important biological activities such as anti-tumour, anti-epileptic, reducing cholesterol, protection of liver and kidney and immunomodulatory, which are of increasing interest, especially its anti-tumour activity. Recent studies demonstrate that the C steroidal glycosides of Baishouwu, which have prominent antitumour efficacy, are one of its main active ingredients. Presently, a variety of C steroidal glycosides have been isolated from Baishouwu medicinal part, the tuberous root. This review summarizes the various antitumour activities of the C steroidal glycosides and their derivatives of Baishouwu.
In this review, the antitumour effects and mechanisms of total C steroidal glycosides and monomers and derivatives of Baishouwu in vitro and in vivo were summarized. Baishouwu can inhibit tumourigenesis by blocking tumour cell cycle progression, regulating numerous signaling pathways, promoting apoptosis, inhibiting tumour cells proliferation and metastasis, improving immunity and so on. This review provides a theoretical basis for inheriting and developing the medical heritage of the motherland, exploring the resources of traditional Chinese medicine for ethnic minorities and clinical rational drug use.
自唐朝末年首次被发现并在宋、明两代兴盛以来，何首乌在中国已使用了数千年。名为何首乌的中药材包括耳叶牛皮消、白首乌和戟叶牛皮消。《本草纲目》记载其“味甘、苦，补肝肾，无毒”。它广泛用于养血祛风、补益肝肾、强健筋骨。
本综述讨论了何首乌C甾体苷及其衍生物在恶性肿瘤方面的研究现状及其抗肿瘤机制。这可能为何首乌及其活性成分在肿瘤治疗中的潜在应用奠定基础。
检索了包括PubMed、Elsevier、Science Direct、谷歌学术、中国知网、万方数据和维普等科学数据库，以收集有关何首乌及其C甾体苷及其衍生物的数据。
既往文献表明，何首乌具有抗肿瘤、抗癫痫、降胆固醇、保护肝肾和免疫调节等重要生物活性，尤其其抗肿瘤活性越来越受到关注。最近的研究表明，何首乌的C甾体苷具有显著的抗肿瘤功效，是其主要活性成分之一。目前，已从何首乌药用部位块根中分离出多种C甾体苷。本综述总结了何首乌C甾体苷及其衍生物的各种抗肿瘤活性。
本综述总结了何首乌总C甾体苷及其单体和衍生物在体外和体内的抗肿瘤作用及机制。何首乌可通过阻断肿瘤细胞周期进程、调节众多信号通路、促进细胞凋亡、抑制肿瘤细胞增殖和转移、提高免疫力等抑制肿瘤发生。本综述为传承和发展祖国医学遗产、挖掘少数民族中医药资源及临床合理用药提供了理论依据。
