Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L7 Canada.
Suncor AgroScience, 2489 North Sheridan Way, Mississauga ON, L5K 1A8 Canada.
Colloids Surf B Biointerfaces. 2022 Jul;215:112487. doi: 10.1016/j.colsurfb.2022.112487. Epub 2022 Mar 29.
Our goal was to develop film-forming polymers to extend the antimicrobial lifetimes of cleaned and disinfected surfaces. Antimicrobial polymers were prepared by first reacting poly(ethylene-alt-maleic anhydride) with isopropylamine, partially consuming the anhydride groups, followed by hydrolysis to give water-soluble, highly anionic polyamide PC3. Chlorination with NaOCl gave PC3Cl with oxidative chlorine contents up to 9 wt%. Dried, 5 µm thick, PC3Cl films, gave log 4 reductions in the concentration of Escherichia coli or Staphylococcus aureus exposed to films. A unique feature of the maleic anhydride copolymer platform was the ability to form covalent grafts to surfaces via anhydride reactions. PC3 solution was impregnated into cellulosic filter paper, heated to form ester linkages with cellulose, followed by chlorination with sodium dichloroisocyanurate dihydrate giving grafted PC3Cl. The treated paper (0.3 wt% PC3Cl) gave a log 4 reduction of E. coli concentration in 30 min.
我们的目标是开发成膜聚合物，以延长清洁和消毒表面的抗菌寿命。抗菌聚合物是通过首先使聚（乙烯-马来酸酐）与异丙胺反应，部分消耗酸酐基团，然后水解得到水溶性、高阴离子性聚酰胺 PC3 来制备的。用次氯酸钠氯化得到氧化氯含量高达 9wt%的 PC3Cl。干燥的、5μm 厚的 PC3Cl 薄膜，可使暴露于薄膜的大肠杆菌或金黄色葡萄球菌的浓度降低 4 个对数级。马来酸酐共聚物平台的一个独特特征是能够通过酸酐反应与表面形成共价接枝。PC3 溶液被浸渍到纤维素滤纸上，加热形成与纤维素的酯键，然后用二氯异氰尿酸二水合钠进行氯化，得到接枝的 PC3Cl。处理过的纸（0.3wt%PC3Cl）在 30 分钟内使大肠杆菌浓度降低 4 个对数级。
