Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Bl. 103A, 1113 Sofia, Bulgaria.
Macromol Biosci. 2010 Aug 11;10(8):944-54. doi: 10.1002/mabi.200900433.
New antimicrobial microfibrous electrospun mats from styrene/maleic anhydride copolymers were prepared. Two approaches were applied: (i) grafting of poly(propylene glycol) monoamine (Jeffamine® M-600) on the mats followed by formation of complex with iodine; (ii) modification of the mats with amines of 8-hydroxyquinoline or biguanide type with antimicrobial activity. Microbiological screening against S. aureus, E. coli and C. albicans revealed that both the formation of complex with iodine and the covalent attachment of 5-amino-8-hydroxyquinoline or of chlorhexidine impart high antimicrobial activity to the mats. In addition, S. aureus bacteria did not adhere to modified mats.
从苯乙烯/马来酸酐共聚物中制备了新的抗菌微纤维电纺垫。采用了两种方法：（i）将聚（丙二醇）单胺（Jeffamine® M-600）接枝到垫子上，然后与碘形成复合物；（ii）用具有抗菌活性的 8-羟基喹啉或双胍类型的胺对垫子进行改性。对金黄色葡萄球菌、大肠杆菌和白色念珠菌的微生物筛选表明，碘复合物的形成和 5-氨基-8-羟基喹啉或洗必泰的共价附着都赋予垫子很高的抗菌活性。此外，改性垫上没有金黄色葡萄球菌细菌附着。
