Mitachi Katsuhiko, Mingle David, Kurosu Michio
Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison, Memphis, TN 38163, USA.
Synthesis (Stuttg). 2021 Aug;53(15):2643-2650. doi: 10.1055/a-1464-2473. Epub 2021 Mar 25.
(4,4'-Bisfluorophenyl)methoxymethyl (BFPM) group of uridine ureido nitrogen shows good relative stability in a variety of chemical transformation reactions for uridine. The BFPM group can be cleaved via 2% of TFA in CHCl without affecting the Boc group.
尿苷脲基氮上的(4,4'-双氟苯基)甲氧基甲基(BFPM)基团在尿苷的各种化学转化反应中表现出良好的相对稳定性。BFPM基团可通过在CHCl中2%的三氟乙酸进行裂解,而不影响叔丁氧羰基(Boc)基团。