Botero Javier Enrique, Posada-López Adriana, Mejía-Vallejo Jimi, Pineda-Tamayo Ricardo Antonio, Bedoya-Giraldo Emilio
Universidad de Antioquia, Facultad de Odontología, Medellín-Colombia.
Artmédica, IPS, Grupo de información clínica, Medellín-Colombia.
Colomb Med (Cali). 2021 Sep 30;52(3):e2095051. doi: 10.25100/cm.v52i3.5051. eCollection 2021 Jul-Sep.
periodontal therapy has been suggested to have systemic effects. However, studies of periodontal therapy in rheumatoid arthritis patients have produced controversial results.
To compare the effects of nonsurgical periodontal therapy on biochemical markers of rheumatoid arthritis and periodontal parameters in patients with and without rheumatoid arthritis.
a prospective before-and-after study was conducted that included 21 participants without and 29 participants with rheumatoid arthritis. Periodontal parameters, detection, C-reactive protein, rheumatoid factor and anti-citrullinated protein antibodies were measured at baseline and three months after nonsurgical periodontal therapy and the changes were statistically assessed.
In general, both groups presented statistically significant improvement in periodontal parameters (<0.05). There was an increase in the counts of in both groups at three months. In addition, there was a reduction in levels of anti-citrullinated protein antibodies and rheumatoid factor in participants with rheumatoid arthritis. In contrast, C-reactive protein levels increased in both groups but were higher in the rheumatoid arthritis group. Periodontal parameters in rheumatoid arthritis participants under disease-modifying antirheumatic drugs presented a slightly higher improvement ( <0.05).
Nonsurgical periodontal therapy has similar improvements in periodontal parameters in patients with and without rheumatoid arthritis. In addition, nonsurgical periodontal therapy may benefit serum levels of anti-citrullinated protein antibodies and rheumatoid factors in patients with rheumatoid arthritis. NCT04658615.
牙周治疗已被认为具有全身效应。然而，针对类风湿关节炎患者进行的牙周治疗研究结果存在争议。
比较非手术牙周治疗对患有和未患类风湿关节炎患者的类风湿关节炎生化指标和牙周参数的影响。
进行了一项前瞻性前后对照研究，纳入21名未患类风湿关节炎的参与者和29名患有类风湿关节炎的参与者。在基线以及非手术牙周治疗后三个月测量牙周参数、检测C反应蛋白、类风湿因子和抗瓜氨酸化蛋白抗体，并对变化进行统计学评估。
总体而言，两组的牙周参数均有统计学显著改善（P<0.05）。三个月时两组的[具体指标]计数均增加。此外，患有类风湿关节炎的参与者中抗瓜氨酸化蛋白抗体和类风湿因子水平降低。相比之下，两组的C反应蛋白水平均升高，但类风湿关节炎组更高。接受改善病情抗风湿药物治疗的类风湿关节炎参与者的牙周参数改善略高（P<0.05）。
非手术牙周治疗对患有和未患类风湿关节炎的患者的牙周参数有相似的改善。此外，非手术牙周治疗可能有益于类风湿关节炎患者的抗瓜氨酸化蛋白抗体和类风湿因子的血清水平。NCT04658615。
