Conlan J W, Baskerville A, Ashworth L A
J Gen Microbiol. 1986 Jun;132(6):1565-74. doi: 10.1099/00221287-132-6-1565.
Six discrete protease activities were recovered from the supernatant broth of Legionella pneumophila cultures by ion-exchange chromatography. One of these demonstrated in vitro activity against collagen, casein and gelatin. When administered into the lungs of guinea-pigs this protease elicited lesions which were pathologically similar to those seen in clinical and experimentally induced Legionnaires' disease.
通过离子交换色谱法从嗜肺军团菌培养物的上清液中分离出六种不同的蛋白酶活性。其中一种在体外对胶原蛋白、酪蛋白和明胶具有活性。当将这种蛋白酶注入豚鼠肺部时，会引发病变，这些病变在病理上与临床和实验诱导的军团病中所见的病变相似。
