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[人及豚鼠嗜肺军团菌感染的组织病理学特征]

[Histopathological characteristics of Legionella pneumophila infection in man and guinea pigs].

作者信息

Kokorin I N, Eruslanov B V, Tartakovskiĭ I S, Petrosov V V, Prozorovskiĭ S V

出版信息

Arkh Patol. 1981;43(4):18-25.

PMID:7236041
Abstract

The current histopathological aspects of legionnaires' disease, a newly discovered acute feverish disease accompanied by severe rapidly progressive pneumonias with 20% mortality are reviewed. Epidemic and sporadic cases of legionnaires' disease occurred both in the United States and many countries of Europe. The gross and microscopic pathology of autopsy specimens from patients with legionnaires' disease and pathological findings in guinea pigs inoculated intraperitoneally with Legionella pneumophilla are discussed. Some methods for isolation of specimens for laboratory diagnosis in severe pneumonias suspect for legionnaires' disease are recommended.

摘要

本文综述了军团病的当前组织病理学特征。军团病是一种新发现的急性发热性疾病,伴有严重的快速进展性肺炎,死亡率达20%。美国和欧洲许多国家均出现过军团病的流行和散发病例。文中讨论了军团病患者尸检标本的大体和显微镜下病理学表现,以及豚鼠腹腔接种嗜肺军团菌后的病理结果。还推荐了一些针对疑似军团病的严重肺炎患者进行实验室诊断时的标本采集方法。

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1
[Histopathological characteristics of Legionella pneumophila infection in man and guinea pigs].[人及豚鼠嗜肺军团菌感染的组织病理学特征]
Arkh Patol. 1981;43(4):18-25.
2
Legionnaires' pneumonia after intratracheal inoculation of guinea pigs and rats.豚鼠和大鼠气管内接种后发生军团菌肺炎。
Lab Invest. 1982 Dec;47(6):568-78.
3
Legionnaires' disease and other newly recognized Legionella-like causes of bacterial pneumonia.军团病及其他新发现的类似军团菌的细菌性肺炎病因。
J Med. 1980;11(4):293-302.
4
Sporadic Legionnaires' disease. A pathologic study of 23 fatal cases.散发性军团病。23例致命病例的病理学研究。
Arch Pathol Lab Med. 1981 Mar;105(3):130-7.
5
Pathologic findings in guinea pigs inoculated intraperitoneally with the Legionnaires' disease bacterium.用军团病细菌腹腔接种豚鼠后的病理结果。
Ann Intern Med. 1979 Apr;90(4):671-5. doi: 10.7326/0003-4819-90-4-671.
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Histopathology of experimental Legionnaires' disease in guinea pigs, rhesus monkeys and marmosets.豚鼠、恒河猴和狨猴实验性军团病的组织病理学
J Pathol. 1983 Mar;139(3):349-62. doi: 10.1002/path.1711390310.
7
Neonatal Legionnaires' disease. Histopathological findings in an autopsied neonate.
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8
Legionnaires' disease pneumonia: histopathologic features and comparison with microbial and chemical pneumonias.
Ann Clin Lab Sci. 1979 Sep-Oct;9(5):353-61.
9
Immunocytochemical demonstration of the association between Legionella pneumophila, its tissue-destructive protease, and pulmonary lesions in experimental legionnaires' disease.免疫细胞化学证实嗜肺军团菌、其组织破坏性蛋白酶与实验性军团病肺部病变之间的关联。
J Pathol. 1987 Nov;153(3):257-64. doi: 10.1002/path.1711530310.
10
Separation of Legionella pneumophila proteases and purification of a protease which produces lesions like those of Legionnaires' disease in guinea pig lung.嗜肺军团菌蛋白酶的分离及一种在豚鼠肺中产生类似军团病病变的蛋白酶的纯化。
J Gen Microbiol. 1986 Jun;132(6):1565-74. doi: 10.1099/00221287-132-6-1565.