Kapfhammer J P, Raper J A
J Neurosci. 1987 Jan;7(1):201-12. doi: 10.1523/JNEUROSCI.07-01-00201.1987.
We have studied the morphology of embryonic chick retinal and sympathetic growth cones as they meet retinal and sympathetic neurites grown in culture. Growth cones preserve their normal morphology and ability to locomote when retinal growth cones contact retinal neurites or when sympathetic growth cones contact sympathetic neurites. Growth cones collapse and their motility ceases when retinal growth cones contact sympathetic neurites or when sympathetic growth cones contact retinal neurites. Collapse was never observed before a growth cone touched a neurite. As a growth cone collapses, the neurite it leads retracts. After a brief pause, a new growth cone is organized and extension recommences. These results suggest that contact-mediated inhibition of locomotion could play a role in growth cone guidance.
我们研究了胚胎期鸡视网膜和交感神经生长锥在与培养的视网膜和交感神经轴突相遇时的形态。当视网膜生长锥与视网膜轴突接触，或者交感神经生长锥与交感神经轴突接触时，生长锥保持其正常形态和移动能力。当视网膜生长锥与交感神经轴突接触，或者交感神经生长锥与视网膜轴突接触时，生长锥会塌陷，其运动能力也会停止。在生长锥接触轴突之前从未观察到塌陷现象。当一个生长锥塌陷时，它所引导的轴突会回缩。短暂停顿后，会形成一个新的生长锥，延伸过程重新开始。这些结果表明，接触介导的运动抑制可能在生长锥导向中发挥作用。
