Dencker S J, Johansson R, Lundin L, Malm U
Acta Psychiatr Scand. 1978 May;57(5):405-14. doi: 10.1111/j.1600-0447.1978.tb06909.x.
The results from this controlled study of 12 schizophrenics refractory to ordinary doses of neuroleptics indicate that treatment with fluphenazine enanthate in higher doses than normal (10--20 times higher) might give reduction in psychopathology beyond what can be obtained with normal doses. In four patients the symptom reduction on high doses was pronounced. Moreover, we found that the high fluphenazine plasma levels demonstrated did not increase extrapyramidal and general side effects. The results presented also speak in favour of certain "non-responding" patients needing a higher plasma level of a neuroleptic drug than the average patient.
这项针对12名对常规剂量抗精神病药物难治的精神分裂症患者的对照研究结果表明，使用高于正常剂量（高10至20倍）的庚酸氟奋乃静进行治疗，可能会使精神病理学症状的减轻程度超过正常剂量所能达到的效果。在4名患者中，高剂量治疗时症状减轻明显。此外，我们发现所测得的高血浆氟奋乃静水平并未增加锥体外系及其他副作用。所呈现的结果还表明，某些“无反应”患者需要比普通患者更高的抗精神病药物血浆水平。
