Coffman J A, Nasrallah H A, Lyskowski J, McCalley-Whitters M, Dunner F J
J Clin Psychiatry. 1987 Jan;48(1):20-4.
A random assignment, double-blind, placebo-controlled evaluation was used to compare the effectiveness of rapid parenteral injections of fluphenazine hydrochloride with that of oral doses of the same drug in 16 patients with acute psychotic illnesses. Doses of fluphenazine hydrochloride were much higher in the parenteral neuroleptization group than in the oral administration group during the acute phase, although oral doses were equivalent during the continuation phase. The rate of improvement was not different for the two groups, but the rate of extrapyramidal side effects was higher in the parenteral neuroleptization group. The results suggest that rapid parenteral neuroleptization for the acute treatment of psychosis offers more risks than benefits.
采用随机分组、双盲、安慰剂对照评估，比较16例急性精神病患者快速胃肠外注射盐酸氟奋乃静与口服相同药物的疗效。在急性期，胃肠外神经安定化组的盐酸氟奋乃静剂量比口服给药组高得多，尽管在维持期口服剂量相当。两组的改善率没有差异，但胃肠外神经安定化组锥体外系副作用的发生率更高。结果表明，快速胃肠外神经安定化用于精神病的急性治疗风险大于益处。
