Abozaid Mortada, Saad-Eldin Rana, Farouk Mahmoud, Anbar Mohamed, Wasfi Ehab
Department of Ophthalmology, Sohag University, Sohag, Egypt.
Department of Rheumatology and Rehabilitation, Sohag University, Sohag, Egypt.
J Ophthalmol. 2022 Apr 6;2022:1153504. doi: 10.1155/2022/1153504. eCollection 2022.
To assess the effects of phacoemulsification on the corneal endothelium in patients with gout and age-related cataracts.
Eighty-eight patients who underwent uneventful phacoemulsification for age-related cataracts were included in this retrospective comparative study. The patients were divided into two groups: group A included 31 patients with gout and tight control of uric acid levels and group B included 57 patients without gout or any other systemic disease. All patients completed follow-up assessments over 6 months, and the two groups were compared in terms of changes to their specular microscopic values.
Both groups showed marked improvement in uncorrected and best-corrected visual acuity at the end of the follow-up period. Corneal endothelial cell loss was more severe in group A than in group B, with a mean difference of 221.35 ± 43.87 in group A and 169.88 ± 52.67 in group B at the sixth month ( < 0.001). The difference between the two groups in terms of other specular microscopic values did not reach statistical significance.
Patients with gout are more prone to corneal endothelial cell damage after phacoemulsification than those without gout. To confirm these results, future studies with a prospective design and longer durations of follow-up are needed.
评估超声乳化术对痛风合并年龄相关性白内障患者角膜内皮的影响。
本回顾性对照研究纳入了88例行超声乳化术治疗年龄相关性白内障且手术过程顺利的患者。患者分为两组：A组包括31例痛风且尿酸水平控制良好的患者，B组包括57例无痛风或其他全身性疾病的患者。所有患者均完成了6个月的随访评估，并比较了两组患者角膜内皮显微镜检查值的变化情况。
随访期末，两组患者的未矫正视力和最佳矫正视力均有显著改善。A组角膜内皮细胞丢失比B组更严重，在第6个月时，A组平均差异为221.35±43.87，B组为169.88±52.67（P<0.001）。两组在其他角膜内皮显微镜检查值方面的差异未达到统计学意义。
痛风患者超声乳化术后比无痛风患者更容易发生角膜内皮细胞损伤。为证实这些结果，需要进行前瞻性设计且随访时间更长的未来研究。
