Kosekahya Pinar, Atilgan Kadir Gokhan, Atilgan Cemile Ucgul, Tekin Kemal, Koc Mustafa, Caglayan Mehtap, Ayli Deniz, Yilmazbas Pelin
Department of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ulucanlar Street, Number: 59, 06240, Ankara, Turkey.
Department of Nephrology, Diskapi Yildirim Beyazıt Training and Research Hospital, Ankara, Turkey.
Int Ophthalmol. 2019 May;39(5):991-1001. doi: 10.1007/s10792-018-0901-7. Epub 2018 Mar 21.
To evaluate the corneal and tear film characteristics in patients with gout and compare these data with those of healthy subjects and to investigate the correlation of corneal densitometry with uric acid value and duration of disease.
Forty-one eyes of 41 patients with gout (group 1) and 40 eyes of 40 healthy subjects (group 2) were included in this study. Detailed ophthalmologic examinations were performed on all participants. Corneal tomographic analyses were performed with the Pentacam HR Scheimpflug imaging system (Oculus, Wetzlar, Germany). Maximum keratometry (K), central corneal thickness (CCT), corneal volume (CV), and corneal densitometric values were compared between groups. Tear function tests including Schirmer, tear breakup time, and fluorescein staining were performed and compared between groups.
Groups were similar in terms of age and gender. K, CCT, and CV values were similar between groups. The outcomes of tear function tests were similar between groups. Corneal densitometric values for the 0-2 and 2-6 mm zones of the anterior and center layers were significantly higher in group 1 compared to group 2. This densitometric increase was positively correlated with uric acid levels and gout duration.
Corneal densitometry values of the 0-2 and 2-6 mm zones of the anterior and central layers were higher in patients with gout than those of the control subjects, and the densitometric values increased as uric acid level and disease duration increased.
评估痛风患者的角膜和泪膜特征，并将这些数据与健康受试者的数据进行比较，同时研究角膜密度测定与尿酸值及疾病持续时间的相关性。
本研究纳入了41例痛风患者的41只眼（第1组）和40例健康受试者的40只眼（第2组）。对所有参与者进行了详细的眼科检查。使用Pentacam HR Scheimpflug成像系统（德国韦茨拉尔的Oculus公司）进行角膜断层分析。比较两组之间的最大角膜曲率（K）、中央角膜厚度（CCT）、角膜体积（CV）和角膜密度值。进行了包括泪液分泌试验、泪膜破裂时间和荧光素染色在内的泪液功能测试，并比较了两组之间的结果。
两组在年龄和性别方面相似。两组之间的K、CCT和CV值相似。泪液功能测试的结果在两组之间相似。与第2组相比，第1组前层和中央层0-2mm和2-6mm区域的角膜密度值显著更高。这种密度增加与尿酸水平和痛风持续时间呈正相关。
痛风患者前层和中央层0-2mm和2-6mm区域的角膜密度测定值高于对照组，且密度值随尿酸水平和疾病持续时间的增加而增加。
