Madan Nikhil, Quintiliani Safiyya, Patel Prutha, Patel Vipul
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Newark Beth Israel Medical Center, New Jersey, 07112, USA.
Division of Lung Transplant, Department of Medicine, University of Maryland Medical Center, Baltimore, MD, 21201, USA.
Respir Med Case Rep. 2022 Apr 4;37:101645. doi: 10.1016/j.rmcr.2022.101645. eCollection 2022.
Shigellae are Gram-negative, nonmotile, facultatively anaerobic, non-spore-forming rods. Shigella is a common cause of gastroenteritis in areas of overcrowding and poor sanitation, but is seen less frequently in the developed world. Infection is mainly acquired through the fecal-oral route, but consumption of unpasteurized dairy remains a high risk for transmission. In the developing world, Shigella is a childhood illness and with adequate hydration is fairly self-limiting. The use of antibiotics depends on the severity of illness, the age of the patient and immune status. In immunocompromised patients, chronic symptomatic or relapsing infection has been described. In this report, we describe a case of a lung transplant patient, one year out of his transplant, on triple immunosuppressive therapy, who presented with septic shock secondary to Shigella gastroenteritis after ingesting unpasteurized cheese brought back from Peru. This case highlights the importance of educating transplant patients on how to reduce certain harmful exposures that may be fatal in immunosuppressed individuals.
志贺氏菌是革兰氏阴性、无动力、兼性厌氧、不形成芽孢的杆菌。在人口密集和卫生条件差的地区,志贺氏菌是肠胃炎的常见病因,但在发达国家较少见。感染主要通过粪-口途径传播,但食用未巴氏杀菌的乳制品仍然是传播的高风险因素。在发展中国家,志贺氏菌病是一种儿童疾病,通过充分补水,病情相当具有自限性。抗生素的使用取决于疾病的严重程度、患者年龄和免疫状态。在免疫功能低下的患者中,已描述有慢性症状性或复发性感染。在本报告中,我们描述了一例肺移植患者,移植后一年,正在接受三联免疫抑制治疗,因食用从秘鲁带回的未巴氏杀菌奶酪后,继发志贺氏菌肠胃炎而出现感染性休克。该病例凸显了对移植患者进行教育的重要性,即如何减少某些可能对免疫抑制个体致命的有害暴露。