Younis Awais, Hardowar Lydia, Barker Sarah, Hulse Richard Philip
School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK.
Curr Res Physiol. 2022 Apr 4;5:184-192. doi: 10.1016/j.crphys.2022.03.005. eCollection 2022.
Nociception is a fundamental acute protective mechanism that prevents harm to an organism. Understanding the integral processes that control nociceptive processing are fundamental to our appreciation of which cellular and molecular features underlie this process. There is an extensive understanding of how sensory neurons interpret differing sensory modalities and intensities. However, it is widely appreciated that the sensory neurons do not act alone. These work in harmony with inflammatory and vascular systems to modulate pain perception. The spinal cord has an extensive interaction with the capillary network in the form of a blood spinal cord barrier to ensure homeostatic control of the spinal cord neuron milieu. However, there is an extensive appreciation that disturbances in the blood spinal cord barrier contribute to the onset of chronic pain. Enhanced vascular permeability and impaired blood perfusion have both been highlighted as contributors to chronic pain manifestation. Here, we discuss the evidence that demonstrates alterations in the blood spinal cord barrier influences nociceptive processing and perception of pain.
伤害感受是一种基本的急性保护机制，可防止生物体受到伤害。了解控制伤害性处理的整体过程对于我们理解该过程背后的细胞和分子特征至关重要。人们对感觉神经元如何解释不同的感觉模式和强度有广泛的了解。然而，人们普遍认识到感觉神经元并非单独起作用。它们与炎症和血管系统协同工作以调节疼痛感知。脊髓与毛细血管网络以血脊髓屏障的形式进行广泛的相互作用，以确保对脊髓神经元环境的稳态控制。然而，人们普遍认识到血脊髓屏障的紊乱会导致慢性疼痛的发生。血管通透性增强和血液灌注受损均被认为是慢性疼痛表现的促成因素。在此，我们讨论表明血脊髓屏障改变会影响伤害性处理和疼痛感知的证据。
