一项基于人群的研究中新型胰岛素敏感性指数FLAIS与心血管危险因素之间的关系。

The relationships between FLAIS, a novel insulin sensitivity index, and cardiovascular risk factors in a population-based study.

作者信息

Karczewska-Kupczewska Monika, Nikołajuk Agnieszka, Kondraciuk Marcin, Stachurska Zofia, Dubatówka Marlena, Szpakowicz Anna, Strączkowski Marek, Kowalska Irina, Kamiński Karol

机构信息

Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, M.C. Skłodowskiej 24a, 15-276, Białystok, Poland.

Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland.

出版信息

Cardiovasc Diabetol. 2022 Apr 19;21(1):55. doi: 10.1186/s12933-022-01491-y.

DOI:10.1186/s12933-022-01491-y

PMID:35439985

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9020075/

Abstract

BACKGROUND

Insulin resistance is a risk factor for cardiovascular disease. Recently, we have developed a novel index, FLAIS (Fasting Laboratory Assessment of Insulin Sensitivity), which accurately reflects insulin sensitivity, measured with hyperinsulinemic-euglycemic clamp, in different groups of subjects. The aim of the present study was to assess the relationship of FLAIS with cardiovascular risk factors in a population-based study.

METHODS

The study group comprised 339 individuals from the ongoing Białystok Plus study, without previously known diabetes. Clinical examination, oral glucose tolerance test and the measurement of blood laboratory parameters were performed.

RESULTS

Prediabetes (impaired fasting glucose and/or impaired glucose tolerance) was diagnosed in 165 individuals whereas type 2 diabetes was diagnosed in 19 subjects. FLAIS was lower in individuals with prediabetes and diabetes in comparison with individuals with normal glucose tolerance. FLAIS was significantly related to waist circumference, systolic and diastolic blood pressure, triglycerides, HDL-cholesterol and LDL-cholesterol in the entire study group and in the subgroups with normal glucose tolerance and with prediabetes/diabetes. HOMA-IR, QUICKI and Matsuda index were not related to blood pressure and LDL-cholesterol in individuals with normal glucose tolerance. Majority of the adjusted models with FLAIS were characterized by better fit with the data in comparison with other indices for all cardiovascular risk factors except waist circumference.

CONCLUSIONS

FLAIS represents useful index to assess the cluster of insulin resistance-associated cardiovascular risk factors in general population.

摘要

背景

胰岛素抵抗是心血管疾病的一个危险因素。最近，我们开发了一种新的指标，即空腹胰岛素敏感性实验室评估（FLAIS），它能准确反映不同受试者群体中通过高胰岛素-正常血糖钳夹法测量的胰岛素敏感性。本研究的目的是在一项基于人群的研究中评估FLAIS与心血管危险因素之间的关系。

方法

研究组由正在进行的比亚韦斯托克加研究中的339名个体组成，这些个体之前未患糖尿病。进行了临床检查、口服葡萄糖耐量试验和血液实验室参数测量。

结果

165名个体被诊断为糖尿病前期（空腹血糖受损和/或糖耐量受损），19名个体被诊断为2型糖尿病。与糖耐量正常的个体相比，糖尿病前期和糖尿病个体的FLAIS较低。在整个研究组以及糖耐量正常和糖尿病前期/糖尿病的亚组中，FLAIS与腰围、收缩压和舒张压、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇显著相关。在糖耐量正常的个体中，HOMA-IR、QUICKI和松田指数与血压和低密度脂蛋白胆固醇无关。除腰围外，与所有心血管危险因素的其他指标相比，大多数包含FLAIS的校正模型与数据的拟合度更好。