Bleeding Complication in a Patient with Concomitant Use of Rivaroxaban and Saffron Supplement: A Case Report.

作者信息

Heidari Zinat, Daei Maryam, Khalili Hossein, Sahebkar Amirhossein

机构信息

Department of Clinical Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Faculty of Pharmacy, Alborz University of Medical Sciences, Alborz, Iran.

出版信息

Cardiovasc Hematol Disord Drug Targets. 2022;22(1):10-12. doi: 10.2174/1871529X22666220418102545.

BACKGROUND

Direct oral anticoagulants (DOACs) carry a lower potential risk of food/herb and drug interactions compared to oral vitamin K antagonists. However, as a new class of medications, drug interactions of DOACs have not been fully known.

CASE PRESENTATION

We herein present the case of a 64-year old male with the complaint of acute onset epistaxis and bleeding gums following the concomitant use of rivaroxaban and saffron supplement. It seems that coadministration of DOACs and saffron supplements should be avoided due to the potential drug-herbal interactions and possible risk of subsequent bleeding complications.

CONCLUSION

However, further larger-scale surveillance studies are needed to confirm the findings and assess the clinical significance.