Stead Victoria E, Schmidt Louis A, Crowley Michael J, Dyce Lisa, Hall Geoffrey B, Van Lieshout Ryan J, Boylan Khrista
Department of Psychology, Neuroscience & Behaviour, McMaster University.
Yale Child Study Center, School of Medicine, Yale University.
Dev Psychopathol. 2023 May;35(2):876-890. doi: 10.1017/S0954579422000128. Epub 2022 Apr 20.
Although associations among borderline personality disorder (BPD), social rejection, and frontal EEG alpha asymmetry scores (FAA, a neural correlate of emotion regulation and approach-withdrawal motivations) have been explored in different studies, relatively little work has examined these relations during adolescence in the same study. We examined whether FAA moderated the relation between BPD features and rejection sensitivity following a validated social exclusion paradigm, Cyberball. A mixed, clinical-community sample of 64 adolescents (females = 62.5%; age = 14.45 years; = 1.6; range = 11-17 years) completed psychodiagnostic interviews and a self-report measure of BPD (Time 1). Approximately two weeks later (Time 2), participants completed a resting EEG recording followed by Cyberball. FAA moderated the relation between BPD features and overall feelings of rejection following Cyberball: individuals with greater relative left FAA had the highest and lowest feelings of social rejection depending on whether they had high and low BPD feature scores, respectively. Results remained after controlling for age, sex, gender, depression, and BPD diagnosis. These results suggest that FAA may moderate the relation between BPD features and social rejection, and that left frontal brain activity at rest may be differentially associated with those feelings in BPD. Findings are discussed in terms of the link between left frontal brain activity in the regulation and dysregulation of social approach behaviors, characteristic of BPD.
尽管在不同研究中已对边缘型人格障碍（BPD）、社会排斥与额叶脑电图α不对称分数（FAA，情绪调节和趋近 - 回避动机的神经关联指标）之间的关联进行了探索，但在同一研究中针对青少年期这些关系的研究相对较少。我们采用经过验证的社会排斥范式“赛博球”（Cyberball），研究了FAA是否调节了BPD特征与拒绝敏感性之间的关系。一个由64名青少年组成的混合临床 - 社区样本（女性占62.5%；年龄 = 14.45岁；标准差 = 1.6；年龄范围 = 11 - 17岁）完成了心理诊断访谈和一份BPD的自我报告测量（时间1）。大约两周后（时间2），参与者完成静息脑电图记录，随后进行“赛博球”实验。FAA调节了“赛博球”实验后BPD特征与总体拒绝感受之间的关系：相对左额叶FAA较高的个体，根据其BPD特征分数高低，分别具有最高和最低的社会拒绝感受。在控制了年龄、性别、抑郁和BPD诊断因素后，结果依然成立。这些结果表明，FAA可能调节BPD特征与社会排斥之间的关系，并且静息状态下左额叶脑活动可能与BPD患者的这些感受存在差异关联。研究结果从BPD特征性的社会趋近行为调节与失调中左额叶脑活动之间的联系方面进行了讨论。
