Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa.
Pediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa.
Acta Biomed. 2022 Mar 21;92(S4):e2021345. doi: 10.23750/abm.v92iS4.12674.
The association between Migraine with Aura (MA) and vascular disease has been previously reported. We investigated whether pre-clinical vascular alterations, such as Endothelial Dysfunction, are already present in children and adolescents with Migraine with Aura.
We retrospectively enrolled 27 patients having Migraine with Aura, aged9 -18 years, and 31 age matched healthy control subjects to evaluateEndothelial Function by Peripheral Arterial Tonometry. This technique measures finger pulse wave amplitude, before and during reactive hyperaemia, and calculates the Augmentation Index (AI) and the Reactive Hyperaemia Index (RHI). We also set-up an Aura Severity Scale to assess disease severity and its relationship with AI and RHI alterations.
Also if the case-control study resulted only partially as significant, we found there is an inversely proportional relationship between the severity of the migraine measured with Aura Severity Scale and the values of the endoscore (a significantly reduced levels of AI (p-value <0,03) and a marginal reduction of RHI levels (p-value <0,07).
Further studies should explore the impact of pre-clinical vascular alterations in children and adolescents with Migraine with Aura.
此前已有报道称偏头痛伴先兆（MA）与血管疾病之间存在关联。我们研究了偏头痛伴先兆的儿童和青少年是否已经存在临床前血管改变，如内皮功能障碍。
我们回顾性地招募了 27 名偏头痛伴先兆的患者，年龄为 9-18 岁，以及 31 名年龄匹配的健康对照者，通过外周动脉张力测定法评估内皮功能。该技术测量手指脉搏波幅度，在反应性充血前后，并计算增强指数（AI）和反应性充血指数（RHI）。我们还建立了一个偏头痛先兆严重程度评分来评估疾病的严重程度及其与 AI 和 RHI 改变的关系。
尽管病例对照研究结果仅部分显著，但我们发现偏头痛先兆严重程度评分与内窥镜评分之间存在反比关系（AI 值显著降低（p 值 <0.03），RHI 值略有降低（p 值 <0.07）。
进一步的研究应探讨临床前血管改变对偏头痛伴先兆的儿童和青少年的影响。
