Center for Stroke Research Berlin, Charité - Universitätsmedizin, Berlin, Germany.
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Headache. 2016 Sep;56(8):1274-9. doi: 10.1111/head.12839. Epub 2016 May 30.
Endothelial dysfunction may contribute to the pathophysiology of migraine with aura. Stromal cell-derived factor-1 alpha (SDF-1α) is involved in the maintenance of endothelial integrity via mobilization of vascular stem cells.
We sought to determine whether SDF-1α levels are decreased in women with MA.
In this post hoc analysis of a case-cohort study, levels of SDF-1α were determined by enzyme-linked immunosorbent assay. Endothelial function was assessed using peripheral arterial tonometry. Arterial stiffness was assessed by fingertip tonometry derived and heart-rate-adjusted augmentation index (AI).
Twenty-eight women with MA and 27 age-matched healthy women were included in this study. Levels of SDF-1α were significantly lower in women with MA compared to age- and risk factor-matched healthy women (1763 ± 281 vs 2013 ± 263 pg/mL, P = 0.006). SDF-1α levels were positively correlated with AI in healthy women (r = 0.49, P = 0.009), but not in women with MA (r = 0.05, P = 0.78). SDF-1α levels were negatively correlated with CD144-positive endothelial microparticles (EMP; r = -0.31, P = .02), and activated CD62E-positive EMP (r = -0.35, P = .01).
Levels of SDF-1α are decreased in women with MA and are associated with EMPs as a surrogate marker of endothelial dysfunction. This might contribute to the pathophysiology and vascular risk in MA, but evidence from larger prospective studies is warranted.
内皮功能障碍可能导致有先兆偏头痛的病理生理学变化。基质细胞衍生因子-1 阿尔法（SDF-1α）通过动员血管干细胞参与维持内皮完整性。
我们旨在确定偏头痛伴先兆（MA）患者的 SDF-1α 水平是否降低。
在一项病例对照研究的事后分析中，通过酶联免疫吸附试验测定 SDF-1α 水平。通过外周动脉张力测定法评估内皮功能。通过指尖张力测定法衍生和心率校正增强指数（AI）评估动脉僵硬。
本研究纳入了 28 例 MA 女性和 27 例年龄匹配的健康女性。与年龄和危险因素匹配的健康女性相比，MA 女性的 SDF-1α 水平显著降低（1763±281 与 2013±263 pg/ml，P=0.006）。SDF-1α 水平与健康女性的 AI 呈正相关（r=0.49，P=0.009），但与 MA 女性无关（r=0.05，P=0.78）。SDF-1α 水平与 CD144 阳性内皮微颗粒（EMP；r=-0.31，P=0.02）和激活的 CD62E 阳性 EMP（r=-0.35，P=0.01）呈负相关。
MA 女性的 SDF-1α 水平降低，与 EMP 作为内皮功能障碍的替代标志物相关。这可能有助于 MA 的病理生理学和血管风险，但需要更大规模的前瞻性研究来证实。
