Department of Laboratory Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Laboratory Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Clin Lab Anal. 2022 Jun;36(6):e24432. doi: 10.1002/jcla.24432. Epub 2022 Apr 20.
Cardiac troponin (cTn) values above the 99th percentile upper reference limit (URL) indicate myocardial injury. We established 99th percentile URLs for three high-sensitivity cTn (hs-cTn) assays (Beckman Coulter Access hs-cTnI, Abbott STAT hs-cTnI, and Roche Elecsys hs-cTnT) using a healthy population in Korea.
Each cTn value was measured by three assays and analyzed by dividing by gender and age.
The frequency histograms of log-transformed cTn values for Beckman and Abbott assays exhibited a bell-shaped distribution. The 99th percentile URLs were 9.8, 17.4, and 17.3 ng/L in the total population; 10.9/9.0, 18.9/17.0, and 18.9/17.7 ng/L in the male/female population (p < 0.001 for all three assays); and 11.2/7.2, 19.9/14.5, and 22.7/9.3 ng/L in the older/younger population (p < 0.001 for all three assays) for Beckman, Abbott, and Roche assays, respectively.
Among the three assays, bell-shaped distributions were observed in a frequency histogram of log-transformed cTn values for healthy population in Beckman and Abbott assays. Also, our findings show that the 99th percentile URLs for cTn levels vary not only by gender but age.
心肌肌钙蛋白（cTn）值超过第 99 百分位上限（URL）表明心肌损伤。我们使用韩国的健康人群建立了三种高敏肌钙蛋白（hs-cTn）检测方法（贝克曼库尔特 Access hs-cTnI、雅培 STAT hs-cTnI 和罗氏 Elecsys hs-cTnT）的第 99 百分位 URL。
通过三种检测方法分别测量每个 cTn 值，并按性别和年龄进行分析。
贝克曼和雅培检测方法的对数转换 cTn 值的频率直方图呈钟形分布。三种检测方法在总人群中的第 99 百分位 URL 分别为 9.8、17.4 和 17.3ng/L；在男性/女性人群中分别为 10.9/9.0、18.9/17.0 和 18.9/17.7ng/L（所有三种检测方法均 p<0.001）；在年龄较大/较小的人群中分别为 11.2/7.2、19.9/14.5 和 22.7/9.3ng/L（所有三种检测方法均 p<0.001）。
在三种检测方法中，贝克曼和雅培检测方法的健康人群对数转换 cTn 值的频率直方图呈钟形分布。此外，我们的研究结果表明，cTn 水平的第 99 百分位 URL 不仅因性别而异，而且因年龄而异。
