Ratzmann K P
Med Interne. 1986 Oct-Dec;24(4):245-52.
Numerous experimental findings in animals as well as epidemiological and clinical observations support the hypothesis that certain viruses play a role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). Directly or via immune and/or autoimmune processes viruses might induce a beta-cell damage. An attempt is made to evaluate critically the arguments for the role of the mumps virus in the pathogenesis of IDDM. Based on their own experience, the authors hold the opinion that at present a causal connection between mumps infection and the development of IDDM cannot be proved beyond doubt. Prospective studies in humans including appropriate techniques of humoral and cellular immunity in relation to the beta-cell damage are required.
动物身上的众多实验结果以及流行病学和临床观察都支持这样一种假说，即某些病毒在胰岛素依赖型糖尿病（IDDM）的发病机制中起作用。病毒可能直接或通过免疫和/或自身免疫过程诱导β细胞损伤。本文试图严格评估关于腮腺炎病毒在IDDM发病机制中作用的论据。基于自身经验，作者认为目前腮腺炎感染与IDDM发病之间的因果关系无法确凿证明。需要对人类进行前瞻性研究，包括与β细胞损伤相关的体液免疫和细胞免疫的适当技术。
