Department of Plastic and Aesthetic Surgery, Nan Fang Hospital, Southern Medical University, Guangzhou, China.
J Cosmet Dermatol. 2022 Oct;21(10):4697-4702. doi: 10.1111/jocd.15011. Epub 2022 May 10.
Local tumescent anesthesia relieves postoperative pain.
The objective of the study was to compare the effect of injecting a tumescent solution with/without ropivacaine on postoperative pain.
A randomized, double-blind control study was conducted in 314 patients who underwent first follicular unit excision after obtaining informed consent and ethics committee approval. The patients were randomly divided into three groups: intra-groups (group 1, injected with tumescent solution with ropivacaine; group 2, without ropivacaine) and inter-group (group 3, right-head/left-head side with/without ropivacaine). Postoperative pain was recorded using the 5-point Wong-Baker Faces Pain Scale. No preoperative analgesic was administered to any patient. The survival rate of hair follicles was measured using dermoscopy during follow-up. Data were statistically analyzed.
Of the 314 patients included in the study, 166 were men and 148 were women with a mean age of 32.15 ± 4.58 (range, 25-45) years. Postoperative pain with ropivacaine was significantly more relieved compared with that without ropivacaine in both groups (p < 0.05). There was no significant difference between sex and survival rate of hair follicles in the intra- or inter-group.
A tumescent solution with ropivacaine has proven to relieve postoperative pain and is a safe and valuable form of local anesthesia in follicular unit excision.
局部肿胀麻醉可缓解术后疼痛。
本研究旨在比较注射含/不含罗哌卡因肿胀液对术后疼痛的影响。
一项随机、双盲对照研究纳入了 314 例经知情同意并获得伦理委员会批准后行首次毛囊单位切取术的患者。患者随机分为三组：组内（组 1，注射含罗哌卡因肿胀液；组 2，不含罗哌卡因）和组间（组 3，右侧/左侧头部分别含/不含罗哌卡因）。采用 Wong-Baker 面部疼痛评分量表记录术后疼痛。所有患者均未给予术前镇痛。随访时采用皮肤镜测量毛囊存活率。对数据进行统计学分析。
本研究共纳入 314 例患者，其中男 166 例，女 148 例，平均年龄 32.15±4.58 岁（25-45 岁）。与不含罗哌卡因相比，两组中含罗哌卡因的肿胀液均能显著减轻术后疼痛（p<0.05）。在组内或组间，性别与毛囊存活率均无显著差异。
含罗哌卡因的肿胀液已被证明可缓解术后疼痛，是毛囊单位切取术局部麻醉的一种安全且有价值的形式。
