Di Somma C, Arnulfo C, Mortola G, Dato D, Serafini P, Rezzo R, Imbimbo B P, Reboa G
Scand J Gastroenterol. 1986 Nov;21(9):1046-50. doi: 10.3109/00365528608996418.
The aim of this study was to compare the effects of pirenzepine with those of atropine a non-selective antimuscarinic agent, on gastroduodenal motor patterns in duodenal ulcer patients. Twenty patients were allocated at random to 2 groups of 10 subjects each. The drugs were administered by bolus intravenous injection as equiactive antisecretory doses of 10 mg pirenzepine and 1 mg atropine. Before and 15 min after drug administration all patients underwent a gastroduodenal manometric and reflexogenic study with a specially designed probe and three inflatable latex balloons. Both drugs significantly decreased antral and duodenal pressure, but atropine was much more effective than pirenzepine: 91 +/- 2% verus 54 +/- 9% decrease in the motility index for the antrum and 95 +/- 1% versus 49 +/- 7% for the duodenum (p less than 0.01). The antral motor threshold was not modified by either drug. The results of this study confirm the selectivity of action of pirenzepine on gastric function.
本研究旨在比较哌仑西平与非选择性抗毒蕈碱剂阿托品对十二指肠溃疡患者胃十二指肠运动模式的影响。20名患者被随机分为2组，每组10名受试者。通过大剂量静脉注射给予药物，哌仑西平10mg和阿托品1mg作为等效的抗分泌剂量。在给药前和给药后15分钟，所有患者均使用专门设计的探头和三个可充气乳胶气球进行胃十二指肠测压和反射性研究。两种药物均显著降低胃窦和十二指肠压力，但阿托品比哌仑西平更有效：胃窦运动指数下降91±2%对54±9%，十二指肠下降95±1%对49±7%（p<0.01）。两种药物均未改变胃窦运动阈值。本研究结果证实了哌仑西平对胃功能作用的选择性。
