Tulassay Z, Szathmári M, Papp J
I. Medizinischen Klinik, Semmelweis Universität Budapest.
Wien Med Wochenschr. 1988 Feb 29;138(4):73-5.
The ulcer healing effect of the combination of pirenzepine and cimetidine was compared to the cimetidine monotherapy in 60 duodenal ulcer patients, in whom previous cimetidine monotherapy (at the dose of 1000 mg/day for 4 weeks) had not produced any healing effect. The study was conducted in a prospective, double blind, random fashion. In 30 patients the cimetidine monotherapy was continued at the dose of 1000 mg/day. The other 30 patients received the combination of pirenzepine (75 mg/day) and cimetidine (400 mg at bedtime). Endoscopy was carried out before and after 4 weeks therapy. In the cimetidine group the ulcers have been cured in 12 cases. The cure rate was higher with the combination therapy: control endoscopy showed healed ulcers in 24 patients in this group. The difference between the two groups is statistically significant (chi 2-Test: 10.0, p less than 0.001). These results indicated a higher effectiveness of the pirenzepine-cimetidine combination in duodenal ulcer patients who had not previously responded to cimetidine alone.
将60例十二指肠溃疡患者中哌仑西平与西咪替丁联合用药的溃疡愈合效果与西咪替丁单药治疗进行比较，这些患者之前接受西咪替丁单药治疗（剂量为1000mg/天，持续4周）未产生任何愈合效果。该研究以前瞻性、双盲、随机方式进行。30例患者继续接受剂量为1000mg/天的西咪替丁单药治疗。另外30例患者接受哌仑西平（75mg/天）与西咪替丁（睡前400mg）联合治疗。在治疗4周前后进行内镜检查。西咪替丁组有12例溃疡治愈。联合治疗的治愈率更高：该组内镜检查显示24例患者溃疡愈合。两组之间的差异具有统计学意义（卡方检验：10.0，p<0.001）。这些结果表明，哌仑西平 - 西咪替丁联合用药对先前单独使用西咪替丁无反应的十二指肠溃疡患者疗效更高。
