Bianchi Porro G, Lazzaroni M, Pace F, Petrillo M
Scand J Gastroenterol. 1986 Nov;21(9):1144-6. doi: 10.3109/00365528608996435.
The effect of cimetidine (400 mg at night) and of low-dose antacid (400 mg of aluminum hydroxide plus 400 mg of magnesium hydroxide four times a day) given alone or in combination was assessed in a double-blind double-dummy endoscopic trial on prevention of duodenal ulcer (DU). Seventy-five outpatients with healed DU were followed up clinically for 1 year and were checked endoscopically after 6 and 12 months of therapy or in case of symptomatic relapse. After 6 and 12 months, 25% and 41%, respectively, of patients treated with cimetidine alone experienced a relapse, compared with 42% and 54% of those treated with antacid alone and 25% and 43% of patients treated with the combination therapy. The differences are not statistically significant. No relevant side effects were observed in patients of any group. It is concluded that long-term prophylactic treatment of DU with low-dose antacid is as safe and effective as cimetidine treatment, whereas a combination of the two drugs does not achieve a therapeutic gain.
在一项预防十二指肠溃疡（DU）的双盲双模拟内镜试验中，评估了单独使用西咪替丁（每晚400毫克）和低剂量抗酸剂（氢氧化铝400毫克加氢氧化镁400毫克，每日4次）或两者联合使用的效果。75例DU愈合的门诊患者进行了为期1年的临床随访，并在治疗6个月和12个月后或出现症状复发时进行内镜检查。6个月和12个月后，单独使用西咪替丁治疗的患者分别有25%和41%复发，单独使用抗酸剂治疗的患者分别为42%和54%，联合治疗的患者分别为25%和43%。差异无统计学意义。任何组的患者均未观察到相关副作用。结论是，低剂量抗酸剂对DU的长期预防性治疗与西咪替丁治疗一样安全有效，而两种药物联合使用并未取得治疗效果。
