Ippoliti A, Elashoff J, Valenzuela J, Cano R, Frankl H, Samloff M, Koretz R
Gastroenterology. 1983 Oct;85(4):875-80.
This study was designed to compare the rates of duodenal ulcer healing and recurrence after treatment with cimetidine or antacid. Patients with endoscopically documented duodenal ulcer received cimetidine, 1200 mg daily, or Mylanta II, 7 oz daily, in a randomized, double-blind trial. For the 69 patients in each group who completed the healing phase of the trial, endoscopic ulcer healing was almost identical. At 2, 4, and 6 wk, the cumulative percent healed on antacid was 33%, 64%, and 80%, and on cimetidine it was 25%, 62%, and 86%. The 114 patients with healed ulcer were observed on no therapy and underwent additional endoscopy to detect recurrences when symptomatic or at 3, 6, and 12 mo. There was no difference in the frequency of recurrences between treatments. At 3 and 6 mo, the cumulative percentages of patients with recurrence were 29% and 56% after antacid therapy and 36% and 55% after cimetidine therapy. Some patient variables were associated with delayed ulcer healing or ulcer recurrence. These included sex, pain frequency, smoking, disease duration, and acid secretion.
本研究旨在比较西咪替丁或抗酸剂治疗后十二指肠溃疡的愈合率和复发率。在内镜检查证实为十二指肠溃疡的患者中，进行了一项随机双盲试验，患者分别接受每日1200毫克西咪替丁或每日7盎司氢氧化铝镁（Mylanta II）治疗。每组中完成试验愈合阶段的69例患者，内镜下溃疡愈合情况几乎相同。在第2、4和6周时，抗酸剂治疗组溃疡累计愈合百分比分别为33%、64%和80%，西咪替丁治疗组分别为25%、62%和86%。114例溃疡愈合患者未接受治疗，当出现症状时或在3、6和12个月时接受额外的内镜检查以检测复发情况。两种治疗方法的复发频率没有差异。在3个月和6个月时，抗酸剂治疗后复发患者的累计百分比分别为29%和56%，西咪替丁治疗后分别为36%和55%。一些患者变量与溃疡愈合延迟或溃疡复发有关。这些变量包括性别、疼痛频率、吸烟、病程和胃酸分泌。
