Department of Cardiology, Hatay Education and Research Hospital, Hatay, Turkey.
Eur Rev Med Pharmacol Sci. 2022 Apr;26(7):2431-2436. doi: 10.26355/eurrev_202204_28477.
Red cell distribution width (RDW), an index of erythrocyte size, is recently found to be associated with inflammation and a high risk for cardiovascular disease. Hyperglycemia, the hallmark of prediabetes (PDM) and diabetes mellitus (DM), causes endothelial dysfunction and a proinflammatory state. We investigated the relationship between RDW and hs-CRP in patients with prediabetes and overt DM.
A total of 155 patients were categorized into 3 groups according to the 2007 guideline for American Diabetes Association: "Type 2 DM" group (n = 45), "PDM" group (n = 60) and "Control" group (n = 50). RDW and hs-CRP levels were measured.
PDM group had higher hs-CRP and RDW levels than the control group (14.3 ± 0.84 vs. 12.7 ± 0.8, p < 0.001 for RDW; (0.91 ± 0.49 vs. 0.55 ± 0.37, p < 0.001 for hs-CRP). Similarly, when compared with the PDM, RDW and hs-CRP levels were higher in the DM group (14.8 ± 0.87 vs. 14.3 ± 0.84, p = 0.002 for RDW; 1.15 ± 0.59 vs. 0.91 ± 0.49, p = 0.03 for hs-CRP).
Prediabetes and diabetes were associated with elevated RDW levels which may be attributed to a subclinical inflammatory background.
红细胞分布宽度（RDW）是红细胞大小的指标，最近发现与炎症和心血管疾病风险增加有关。高血糖是糖尿病前期（PDM）和糖尿病的标志，可导致内皮功能障碍和促炎状态。我们研究了 RDW 与 PD 及显性 DM 患者超敏 C 反应蛋白（hs-CRP）之间的关系。
根据 2007 年美国糖尿病协会指南，将 155 例患者分为 3 组：“2 型糖尿病”组（n=45）、“PDM”组（n=60）和“对照组”（n=50）。测量 RDW 和 hs-CRP 水平。
PDM 组的 hs-CRP 和 RDW 水平高于对照组（14.3±0.84 与 12.7±0.8，p<0.001；0.91±0.49 与 0.55±0.37，p<0.001）。同样，与 PDM 相比，DM 组的 RDW 和 hs-CRP 水平更高（14.8±0.87 与 14.3±0.84，p=0.002；1.15±0.59 与 0.91±0.49，p=0.03）。
PDM 和糖尿病与 RDW 水平升高有关，这可能归因于亚临床炎症背景。
