Ophthalmology Department, Taipei City Hospital, Taipei, Taiwan.
Ocul Immunol Inflamm. 2022 Jul;30(5):1278-1281. doi: 10.1080/09273948.2022.2062388. Epub 2022 Apr 20.
To report a case of multiple evanescent white dot syndrome (MEWDS) following severe acute respiratory syndrome coronavirus 2 vaccination.
Case report.
A 36-year-old healthy Taiwanese female was presented with flashing lights in the right eye two days after the first dose of Medigen Vaccine Biologics Corporation (MVC) coronavirus disease 19 (COVID-19) vaccine. Examination of the retina revealed multiple white dots in the posterior pole extending to the mid-periphery. Disruption of ellipsoid zone on optical coherence tomography, early hyperfluorescence on fluorescein angiography, late hypo-cyanescence on indocyanine green angiography, and paracentral scotoma on visual field test were consistent with MEWDS. At four-week follow-up, the patient's fundus lesions resolved, and symptoms subsided without treatment.
Resembling previous post-vaccine MEWDs cases, the symptoms are self-limited, and the visual prognosis is excellent. The presented case demonstrates MEWDS following MVC COVID-19 vaccine and suggests the immune-mediated basis for MEWDS in predisposed patients.
报告一例接种严重急性呼吸综合征冠状病毒 2 型疫苗后出现多发性一过性白点综合征（MEWDS）的病例。
病例报告。
一名 36 岁健康的中国台湾女性在接种美迪吉生物科技公司（MVC）新冠肺炎疫苗第一剂后两天出现右眼闪光。眼底检查发现后极部至中周部有多个白色斑点。光相干断层扫描显示椭圆体带中断，荧光素血管造影早期呈强荧光，吲哚青绿血管造影晚期呈低荧光，视野检查呈旁中心暗点，均符合 MEWDS 表现。四周随访时，患者眼底病变消退，症状自行缓解，无需治疗。
与既往疫苗接种后 MEWDS 病例相似，症状为自限性，视力预后良好。本例提示 MVC 新冠肺炎疫苗接种后可能出现 MEWDS，并提示易感患者的 MEWDS 可能存在免疫介导机制。
