Xu G Y, Zhu H S, Liu W J, Zeng Z W, Wang J X, Han T W, Zhou S H, Liu J, Xiao F Z
Fujian Provincial Center for Disease Control and Prevention/Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou 350012, China College of Public Health, Fujian Medical University, Fuzhou 350122, China.
Fujian Provincial Center for Disease Control and Prevention/Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou 350012, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2022 Apr 10;43(4):548-553. doi: 10.3760/cma.j.cn112338-20210819-00664.
To analyze the incidence of leptospirosis in Fujian province from 2015 to 2020 and provide the scientific evidences for the risk assessment, prevention and control of leptospirosis. The incidence data of leptospirosis in Fujian during 2015-2020 were collected from China Information System for Disease Control and Prevention for a descriptive analysis, and software ArcGIS 10.3.1 was used for spatial autocorrelation analysis, and rats were captured in 17 surveillance areas during the same period, and the rat organs were collected for pathogen culture, the level of antibody was detected in serum samples of rats, healthy population and the serum samples of patients sent by the hospitals. The infection status of in human and rats were analyzed. The incidence of leptospirosis in Fujian showed a downward trend from 2015 to 2020. A total of 176 cases of leptospirosis were reported. There were obvious seasonality and bimodal distribution. The majority of cases were farmers, accounting for 49.43% (87/176). Most cases were aged 30-69 years (85.80%, 151/176). The male to female ratio of the cases was 3.51∶1 (137∶39). Spatial autocorrelation analysis showed that leptospirosis had high or low clustering areas. From 2015 to 2020, the average capture rate of rats in 17 surveillance areas was 6.96% (1 519/21 838), , and were the main species. The average positive rate of antibody in rats was 28.64% (252/880). and were the predominant serogroups, accounting for 56.75% (143/252) and 17.46% (44/252), respectively. The average positive rate of antibody in healthy population was 16.13% (254/1 575), and and were the predominant serogroups, accounting for 71.65% (182/254). The confirmation rate of leptospirosis in patient serum samples sent by the hospitals was 2.23% (188/8 431), (56.38%, 106/188) and (19.68%, 37/188) were the major serogroups. The incidence of leptospirosis in Fujian showed a downward trend from 2015 to 2020, there were obvious area clustering and seasonality. The high clustering areas were mainly distributed in northern, western and central Fujian. and were the predominant serogroups in rats. The infection rate in healthy population decreased year by year. and were the main serogroups in population in Fujian.
分析2015 - 2020年福建省钩端螺旋体病的发病情况，为钩端螺旋体病的风险评估、预防和控制提供科学依据。收集中国疾病预防控制信息系统中福建省2015 - 2020年钩端螺旋体病的发病数据进行描述性分析，采用ArcGIS 10.3.1软件进行空间自相关分析，同期在17个监测地区捕获鼠类，采集鼠脏器进行病原体培养，检测鼠血清样本、健康人群血清样本及医院送检患者血清样本的抗体水平，分析人和鼠的感染状况。2015 - 2020年福建省钩端螺旋体病发病率呈下降趋势，共报告176例钩端螺旋体病病例，有明显的季节性和双峰分布。病例以农民居多，占49.43%（87/176）。多数病例年龄在30 - 69岁（85.80%，151/176）。病例男女比例为3.51∶1（137∶39）。空间自相关分析显示钩端螺旋体病存在高聚集区或低聚集区。2015 - 2020年17个监测地区鼠类平均捕获率为6.96%（1519/21838）， 和 为主要鼠种。鼠类 抗体平均阳性率为28.64%（252/880）。 和 为优势血清群，分别占56.75%（143/252）和17.46%（44/252）。健康人群 抗体平均阳性率为16.13%（254/1575）， 和 为优势血清群，占71.65%（182/254）。医院送检患者血清样本中钩端螺旋体病确诊率为2.23%（188/8431）， （56.38%，106/188）和 （19.68%，37/188）为主要血清群。2015 - 2020年福建省钩端螺旋体病发病率呈下降趋势，有明显的地区聚集性和季节性。高聚集区主要分布在福建北部、西部和中部。 和 是鼠类的优势血清群。健康人群感染率逐年下降。 和 是福建人群中的主要血清群。
