中性粒细胞与淋巴细胞比值及红细胞分布宽度与 2 型糖尿病患者微量白蛋白尿的相关性研究。

A Study on Correlation of Neutrophil to Lymphocyte Ratio and Red Cell Distribution Width with Microalbuminuria in Type 2 Diabetes Mellitus.

机构信息

Kalinga institute of Medical Sciences, Bhubaneswar.

出版信息

J Assoc Physicians India. 2022 Apr;70(4):11-12.

Abstract

UNLABELLED

Diabetes mellitus (DM) is a systemic disease having serious microvascular and macrovascular complications. DM is one of the most common causes of chronic kidney disease CKD, end-stage renal disease (ESRD). Chronic inflammation has an important role in the development and progression of type 2 diabetes through immunologic inflammatory mechanisms. Simple new inexpensive inflammatory markers may contribute to the detection of microalbuminuria. Our aim is to study the correlation of neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW) with microalbuminuria in type 2 diabetic patients.

MATERIAL

This was a single-center, cross-sectional study and was conducted from November 2020 to October 2021 in a tertiary care center in Eastern Odisha. Study subjects were patients with type 2 Diabetes Mellitus. A total of 90 patients with type 2 diabetes mellitus were classified into gender- and BMI-matched three groups according to hemoglobin A1c and microalbuminuria: Group A: 30 patients with controlled diabetes, without microalbuminuria Group B: 30 patients with uncontrolled diabetes, without microalbuminuria, and Group C: 30 patients with uncontrolled diabetes with microalbuminuria. Levels of NLR and RDW between the study groups were examined and compared.

OBSERVATION

A significant difference in NLR was found between Group C and groups A and B (P <.001, P =.008, respectively). A statistically significant difference in RDW was found between groups B and C (P =.015). Receiver operating characteristic curve analysis of inflammatory markers and microalbuminuria prediction showed an area under the curve (AUC) of 0.69 for NLR and 0.61 for RDW.

CONCLUSION

NLR and RDW have a positive correlation with urine ACR and have PPV for microalbuminuria in diabetic patients. NLR and RDW are cheap and inexpensive methods for detecting nephropathy early in diabetes patients.

摘要

未加标签

糖尿病（DM）是一种全身性疾病，具有严重的微血管和大血管并发症。DM 是慢性肾脏病（CKD）、终末期肾病（ESRD）的最常见原因之一。慢性炎症通过免疫炎症机制在 2 型糖尿病的发生和发展中起重要作用。简单的新的廉价炎症标志物可能有助于检测微量白蛋白尿。我们的目的是研究中性粒细胞与淋巴细胞比值（NLR）和红细胞分布宽度（RDW）与 2 型糖尿病患者微量白蛋白尿的相关性。

材料

这是一项单中心、横断面研究，于 2020 年 11 月至 2021 年 10 月在东奥里萨邦的一家三级保健中心进行。研究对象为 2 型糖尿病患者。根据糖化血红蛋白和微量白蛋白尿，将 90 例 2 型糖尿病患者分为性别和 BMI 匹配的三组：A 组：30 例血糖控制良好，无微量白蛋白尿；B 组：30 例血糖控制不佳，无微量白蛋白尿；C 组：30 例血糖控制不佳，有微量白蛋白尿。检查并比较了研究组之间 NLR 和 RDW 的水平。