Alirezaei Amirhesam, Toudeshki Kimia Karimi, Taherian Masoumeh, Pashapour Hadi, Rahmani Fatemeh, Norouzi Najmeh, Fazeli Seyed Amirhossein
Department of Nephrology, Clinical Research and Development Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Cardiology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Res Med Sci. 2024 Oct 24;29:66. doi: 10.4103/jrms.jrms_150_24. eCollection 2024.
Proteinuria is a key indicator of kidney damage in diabetic nephropathy, and its severity correlates with the progression of the disease. In diabetic patients, it is crucial to identify reliable predictors for proteinuria and its severity for early detection and management of kidney damage.
This cross-sectional study was conducted from November 16, 2022, to May 20, 2023, on patients with type 2 diabetes mellitus (T2DM) who were outpatients at clinics of Shahid Modarres Hospital, Tehran, Iran. Participants were categorized based on their level of proteinuria during 24-h as follows: group A1 (normal to mildly increased proteinuria), Group A2 (moderately increased proteinuria), and Group A3 (severely increased proteinuria). Then, complete blood cell count and other laboratory parameters, were compared between study groups.
In this cross-sectional study, 128 participants, including 53 (41.4%) men and 75 (58.6%) women with T2DM, were enrolled. The mean age of participants was 56.40 ± 13.31 years. Although there were no significant differences between cell count and parameters of three groups, a statistically significant difference was seen in neutrophil-to-lymphocyte ratio (NLR) (1.93 ± 0.76, 2.34 ± 0.93, and 2.73 ± 1.07 in A1, A2, and A3 groups, respectively; = 0.003). Further analysis showed that NLR was significantly higher in Group A3 compared to A1 (2.73 ± 1.07 vs. 1.93 ± 0.76, respectively; = 0.006), but there was no significant difference between Groups A3 and A2 (2.73 ± 1.07 vs. 2.34 ± 0.93, respectively; = 0.482) and between Groups A2 and A1 (2.34 ± 0.93 vs. 1.93 ± 0.76, respectively; = 0.257).
Overall, this study suggests that some routine laboratory parameters may be associated with proteinuria and its severity in patients with T2DM. NLR, in particular, showed this association in our study, promising future studies evaluating this association and whether it can help as a predictor or not.
蛋白尿是糖尿病肾病中肾脏损伤的关键指标，其严重程度与疾病进展相关。对于糖尿病患者，识别蛋白尿及其严重程度的可靠预测指标对于早期发现和管理肾脏损伤至关重要。
本横断面研究于2022年11月16日至2023年5月20日对伊朗德黑兰沙希德·莫达雷斯医院门诊的2型糖尿病（T2DM）患者进行。参与者根据其24小时蛋白尿水平分为以下几组：A1组（蛋白尿正常至轻度增加）、A2组（蛋白尿中度增加）和A3组（蛋白尿重度增加）。然后，比较研究组之间的全血细胞计数和其他实验室参数。
在本横断面研究中，共纳入128名参与者，其中包括53名（41.4%）男性和75名（58.6%）女性T2DM患者。参与者的平均年龄为56.40±13.31岁。虽然三组的细胞计数和参数之间没有显著差异，但中性粒细胞与淋巴细胞比值（NLR）存在统计学显著差异（A1、A2和A3组分别为1.93±0.76、2.34±0.93和2.73±1.07；P = 0.003）。进一步分析表明，A3组的NLR显著高于A1组（分别为2.73±1.07和1.93±0.76；P = 0.006），但A3组和A2组之间（分别为2.73±1.07和2.34±0.93；P = 0.482）以及A2组和A1组之间（分别为2.34±0.93和1.93±0.76；P = 0.257）没有显著差异。
总体而言，本研究表明一些常规实验室参数可能与T2DM患者的蛋白尿及其严重程度相关。特别是NLR在我们的研究中显示出这种关联，这为未来评估这种关联以及它是否可作为预测指标的研究带来了希望。
