WT1 β'ing catenin into shape: a new interaction driving epigenetic plasticity in acute myeloid leukemia?
作者信息
Grey William
机构信息
York Biomedical Research Institute, Department of Biology, University of York.
出版信息
Haematologica. 2023 Jan 1;108(1):5-6. doi: 10.3324/haematol.2022.281119.
Abstract
摘要
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本文引用的文献
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Crosstalk between β-catenin and WT1 signaling activity in acute myeloid leukemia.急性髓系白血病中β-连环蛋白与WT1信号活性之间的串扰
Haematologica. 2023 Jan 1;108(1):283-289. doi: 10.3324/haematol.2021.280294.
2
Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia.人类 AML 的功能重建揭示了干细胞起源和治疗抵抗性 MLL 重排白血病的脆弱性。
Sci Transl Med. 2021 Feb 24;13(582). doi: 10.1126/scitranslmed.abc4822.
3
WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target.WT1 通过上调 BCL2L2 促进白血病起始细胞的自我更新：WT1-BCL2L2 轴作为急性髓系白血病的新治疗靶点。
J Transl Med. 2020 Jun 24;18(1):254. doi: 10.1186/s12967-020-02384-y.
4
LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells.LEF-1 驱动髓系白血病细胞中异常的 β-连环蛋白核定位。
Haematologica. 2019 Jul;104(7):1365-1377. doi: 10.3324/haematol.2018.202846. Epub 2019 Jan 10.
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Transcriptional memory of cells of origin overrides β-catenin requirement of MLL cancer stem cells.起源细胞的转录记忆超越了MLL癌干细胞对β-连环蛋白的需求。
EMBO J. 2017 Nov 2;36(21):3139-3155. doi: 10.15252/embj.201797994. Epub 2017 Oct 4.
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Myeloid malignancies in the real-world: Occurrence, progression and survival in the UK's population-based Haematological Malignancy Research Network 2004-15.真实世界中的髓系恶性肿瘤：英国基于人群的血液恶性肿瘤研究网络 2004-2015 年的发病、进展和生存情况。
Cancer Epidemiol. 2016 Jun;42:186-98. doi: 10.1016/j.canep.2016.03.011. Epub 2016 Apr 16.
7
BET inhibitor resistance emerges from leukaemia stem cells.白血病干细胞产生对BET抑制剂的耐药性。
Nature. 2015 Sep 24;525(7570):538-42. doi: 10.1038/nature14888. Epub 2015 Sep 14.
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Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.组蛋白甲基转移酶DOT1L对Wnt信号靶基因表达的调控
ACS Chem Biol. 2015 Jan 16;10(1):109-14. doi: 10.1021/cb500668u. Epub 2014 Nov 10.
9
Mechanisms of transcriptional regulation by WT1 (Wilms' tumour 1).WT1（肾母细胞瘤 1 号基因）转录调控的机制。
Biochem J. 2014 Jul 1;461(1):15-32. doi: 10.1042/BJ20131587.
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Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.经典 Wnt 信号通路以剂量依赖的方式调控造血。
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